ArticleNeurogastroenterology and motility2010
Gastric emptying of enterally administered liquid meal in conscious rats and during sustained anaesthesia.
Article in Neurogastroenterology and motility, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Dynamic Magnetic Resonance Imaging of Whole-Stomach Motility in Rats.NMR in biomedicine · 2025Article
- Regional Heterogeneity in Intestinal Epithelial Barrier Permeability and Mesenteric Perfusion After Thoracic Spinal Cord Injury.Digestive diseases and sciences · 2024Article
- Brainstem Neuronal Circuitries Controlling Gastric Tonic and Phasic Contractions: A Review.Cellular and molecular neurobiology · 2022Review
- Chase Dosing of Lipid Formulations to Enhance Oral Bioavailability of Nilotinib in Rats.Pharmaceutical research · 2020Article
- Gastric vagal afferent neuropathy following experimental spinal cord injury.Experimental neurology · 2020Article
- Gastrointestinal dysfunction after spinal cord injury.Experimental neurology · 2019Review
- Opportunities and Challenges for Single-Unit Recordings from Enteric Neurons in Awake Animals.Micromachines · 2018Review
- Anatomical and Functional Changes to the Colonic Neuromuscular Compartment after Experimental Spinal Cord Injury.Journal of neurotrauma · 2018Article
- Diminished gastric prokinetic response to ghrelin in a rat model of spinal cord injury.Neurogastroenterology and motility · 2018Article
- Mesenteric vascular dysregulation and intestinal inflammation accompanies experimental spinal cord injury.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- Gastric dysregulation induced by microinjection of 6-OHDA in the substantia nigra pars compacta of rats is determined by alterations in the brain-gut axis.American journal of physiology. Gastrointestinal and liver physiology · 2014Article
- Central nervous system control of gastrointestinal motility and secretion and modulation of gastrointestinal functions.Comprehensive Physiology · 2014Review
- Fabrication and implantation of miniature dual-element strain gages for measuring in vivo gastrointestinal contractions in rodents.Journal of visualized experiments : JoVE · 2014Article
- Electrical bioimpedance and other techniques for gastric emptying and motility evaluation.World journal of gastrointestinal pathophysiology · 2012Article
- Upper gastrointestinal dysmotility after spinal cord injury: is diminished vagal sensory processing one culprit?Frontiers in physiology · 2012Article
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3 authors.
Funding
Abstract
backgroundGastric motility studies are frequently conducted with anaesthetized animal models. Some studies on the same animal species have reported differences in vagal control of the stomach that could not be explained solely by slightly different experimental conditions. A possible limitation in the comparison between similar studies relates to the use of different anaesthetic agents. Furthermore, anaesthetic effects may also limit generalizations between mechanistic studies of gastric function and the gastric function of conscious animals. In the present study, we used the [(13)C]-breath test following a liquid mixed-nutrient test meal (Ensure), 1 ml) with the aim to investigate the rate of gastric emptying in animals that were either conscious or anaesthetized with either Inactin or urethane.
methodsOne week after determining the maximum (13)CO(2) concentration, time to peak [(13)C] recovery and gastric half emptying time in control, conscious rats, we repeated the experiment in the same rats anaesthetized with Inactin or urethane. KEY
resultsOur data show that Inactin anaesthesia prolonged the time to peak [(13)C] recovery but did not significantly reduce the maximum (13)CO(2) concentration nor delay gastric half emptying time. Conversely, urethane anaesthesia resulted in a significant slowing of all parameters of gastric emptying as measured by the maximum (13)CO(2) concentration, time to peak [(13)C] recovery and half emptying time. CONCLUSIONS & INFERENCES: Our data indicate that Inactin(R) anaesthesia does not significantly affect gastric emptying while urethane anaesthesia profoundly impairs gastric emptying. We suggest that Inactin(R), not urethane, is the more suitable anaesthetic for gastrointestinal research.
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