ArticleMolecular and cellular biology1990
A DNA signal from the Thy-1 gene defines de novo methylation patterns in embryonic stem cells.
Article in Molecular and cellular biology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 75 citations in OpenAlex.
- DNA methylation signatures for breast cancer classification and prognosis.Genome medicine · 2012Review
- Analysis of hypermethylation in the RPS element suggests a signal function for short inverted repeats in de novo methylation.Plant molecular biology · 2002Article
- DNA methylation of helper virus increases genetic instability of retroviral vector producer cells.Journal of virology · 2000Article
- DNA methylation is a reversible biological signal.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Consistent, persistent expression from modified retroviral vectors in murine hematopoietic stem cells.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Inhibition of tumorigenesis by a cytosine-DNA, methyltransferase, antisense oligodeoxynucleotide.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Hordein promoter methylation and transcriptional activity in wild-type and mutant barley endosperm.Molecular & general genetics : MGG · 1996Article
- The initiation of de novo methylation of foreign DNA integrated into a mammalian genome is not exclusively targeted by nucleotide sequence.Journal of virology · 1995Article
- Multiple modifications in cis elements of the long terminal repeat of retroviral vectors lead to increased expression and decreased DNA methylation in embryonic carcinoma cells.Journal of virology · 1995Article
- Binding of histone H1e-c variants to CpG-rich DNA correlates with the inhibitory effect on enzymic DNA methylation.The Biochemical journal · 1995Article
- Demethylation of somatic and testis-specific histone H2A and H2B genes in F9 embryonal carcinoma cells.Molecular and cellular biology · 1993Article
- Expression of the lacZ gene targeted to the HPRT locus in embryonic stem cells and their derivatives.Transgenic research · 1993Article
- Methylation changes in the apolipoprotein AI gene during embryonic development of the mouse.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- Biological aspects of cytosine methylation in eukaryotic cells.Experientia · 1991Review
- DNA methylation and gene expression.Microbiological reviews · 1991Review
- Spreading of DNA methylation across integrated foreign (adenovirus type 12) genomes in mammalian cells.Journal of virology · 1991Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although DNA can be extensively methylated de novo when introduced into pluripotent cells, the CpG island in the Thy-1 gene does not become methylated either in the mouse embryo or in embryonic stem cells. A 214-base-pair region near the promoter of the Thy-1 gene protects itself as well as heterologous DNA sequences from de novo methylation. We propose that this nucleotide sequence is representative of a class of important signals that limits de novo methylation in the embryo and establishes the pattern of hypomethylated CpG dinucleotides found in somatic tissues.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.