ArticleNature nanotechnology2009
Single europium-doped nanoparticles measure temporal pattern of reactive oxygen species production inside cells.
Article in Nature nanotechnology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 98 citations in OpenAlex.
- Linking Experimental Models to Pathophysiology: Oxidative Stress and DNA Damage in Cardiovascular Diseases.International journal of molecular sciences · 2026Review
- Real-timeBiomedical optics express · 2023Article
- ROS and diseases: role in metabolism and energy supply.Molecular and cellular biochemistry · 2020Review
- Biphasic Sol-Gel Synthesis of Microstructured/Nanostructured YVOACS omega · 2019Article
- Enhancement of EuACS omega · 2019Article
- Excimer Emission of Acridine Orange Adsorbed on Gadolinium-Yttrium Orthovanadate Nanoparticles.Journal of fluorescence · 2018Article
- Ultra-wide range field-dependent measurements of the relaxivity of GdScientific reports · 2017Article
- Facile and Chemically Pure Preparation of YVO4:Eu(3+) Colloid with Novel Nanostructure via Laser Ablation in Water.Scientific reports · 2016Article
- Article
- Sensing the dynamics of oxidative stress using enhanced absorption in protein-loaded random media.Scientific reports · 2013Article
- Nano-TiO₂ particles impair adhesion of airway epithelial cells to fibronectin.Respiratory physiology & neurobiology · 2013Article
- Optically stable biocompatible flame-made SiO2-coated Y2O3:Tb3+ nanophosphors for cell imaging.ACS nano · 2012Article
- Recent advances in intracellular and in vivo ROS sensing: focus on nanoparticle and nanotube applications.International journal of molecular sciences · 2012Review
- Facile Synthesis of Amine-Functionalized Eu(3+)-Doped La(OH)3 Nanophosphors for Bioimaging.Nanoscale research letters · 2011Article
- Reactive oxygen species driven angiogenesis by inorganic nanorods.Nano letters · 2011Article
- Single-molecule detection of H₂O₂ mediating angiogenic redox signaling on fluorescent single-walled carbon nanotube array.ACS nano · 2011Article
- Light-activated regulation of cofilin dynamics using a photocaged hydrogen peroxide generator.Journal of the American Chemical Society · 2010Article
- Imaging gap junctions with silica-coated upconversion nanoparticles.Medical & biological engineering & computing · 2010Article
- Detection of single-molecule H2O2 signalling from epidermal growth factor receptor using fluorescent single-walled carbon nanotubes.Nature nanotechnology · 2010Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Low concentrations of reactive oxygen species, notably hydrogen peroxide (H(2)O(2)), mediate various signalling processes in the cell. Production of these signals is highly regulated and a suitable probe is needed to measure these events. Here, we show that a probe based on a single nanoparticle can quantitatively measure transient H(2)O(2) generation in living cells. The Y(0.6)Eu(0.4)VO(4) nanoparticles undergo photoreduction under laser irradiation but re-oxidize in the presence of oxidants, leading to a recovery in luminescence. Our probe can be regenerated and reliably detects intracellular H(2)O(2) with a 30-s temporal resolution and a dynamic range of 1-45 microM. The differences in the timing of intracellular H(2)O(2) production triggered by different signals were also measured using these nanoparticles. Although the probe is not selective towards H(2)O(2), in many signalling processes H(2)O(2) is, however, the dominant oxidant. In conjunction with appropriate controls, this probe is a powerful tool for unravelling pathways that involve reactive oxygen species.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.