Evidence map›Paper›PMID 19734454›Full record

ReviewJournal of dental research2009

Post-translational Regulation of Runx2 in Bone and Cartilage.

J H Jonason, G Xiao, M Zhang, L Xing, D Chen

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of dental research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 156 citations in OpenAlex.

  1. Review
  2. Review
  3. Early determination of the dorsal-ventral axis in endochondral ossification in mice.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. A Model of Immediate Implant Placement to Evaluate Early Osseointegration in 129/Sv Diabetic Mice.The International journal of oral & maxillofacial implants · 2023
    Article
  12. Article
  13. Article
  14. Article
  15. Characterization of Chromatin Accessibility in Fetal Bovine Chondrocytes.Animals : an open access journal from MDPI · 2023
    Article
  16. Review
  17. Novel Role of the SIRT1 in Endocrine and Metabolic Diseases.International journal of biological sciences · 2023
    Review
  18. Article
  19. From mesenchymal niches to engineeredMaterials today. Bio · 2022
    Article
  20. Cyclophilin A Promotes Osteoblast Differentiation by Regulating Runx2.International journal of molecular sciences · 2022
    Article

21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

J H JonasonDepartment of Orthopaedics, Center for Musculoskeletal Research, University of Rochester School of Medicine, 601 Elmwood Avenue, Box 665, Rochester, NY 14642, USA.
G Xiao
M Zhang
L Xing
D Chen
University of Pittsburgh · USUniversity of Rochester · US

Funding

Training in Orthopaedic Researchhttps://apps.era.nih.gov/grantfolder/viewInternalGF.era?applId=8841318&folderId=90T32AR053459 · NIAMS · UNIVERSITY OF ROCHESTER · PI ZUSCIK, MICHAEL J · 2006 to 2017
$3.4M
The Mechanism through which TGF-Beta Maintains Chondrocytes in Proliferating StagR01AR054465 · NIAMS · UNIVERSITY OF ROCHESTER · PI CHEN, DI · 2007 to 2018
$2.7M
Roles of Smurf1 in Cbfa1 Degradation and Bone FormationR01AR051189 · NIAMS · UNIVERSITY OF ROCHESTER · PI CHEN, DI · 2004 to 2008
$1.5M
Role of ATF-4 in the Anabolic Actions of PTH on BoneR01DK072230 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI XIAO, GUOZHI · 2007 to 2011
$1.4M
Proteasomal regulation of TNF-mediated local bone lossR21AR053586 · NIAMS · UNIVERSITY OF ROCHESTER · PI XING, LIANPING · 2006 to 2007
$304k
Proteasomal Regulation of BMP Signaling in Bone CellsK02AR052411 · NIAMS · UNIVERSITY OF ROCHESTER · PI CHEN, DI · 2006 to 2008
$301k
NIAMS NIH HHS K02 AR052411NIAMS NIH HHS K02-AR052411NIAMS NIH HHS R01 AR051189NIAMS NIH HHS R01-AR051189NIAMS NIH HHS R01 AR054465NIAMS NIH HHS R01-AR054465NIAMS NIH HHS R21 AR053586NIAMS NIH HHS R21-AR53586NIAMS NIH HHS T32 AR053459NIAMS NIH HHS T32-AR053459NIDDK NIH HHS R01 DK072230NIDDK NIH HHS R01-DK072230
6 · The paper itself

Abstract

The Runx2 gene product is essential for mammalian bone development. In humans, Runx2 haploinsufficiency results in cleidocranial dysplasia, a skeletal disorder characterized by bone and dental abnormalities. At the molecular level, Runx2 acts as a transcription factor for genes expressed in hypertrophic chondrocytes and osteoblasts. Runx2 gene expression and protein function are regulated on multiple levels, including transcription, translation, and post-translational modification. Furthermore, Runx2 is involved in numerous protein-protein interactions, most of which either activate or repress transcription of target genes. In this review, we discuss expression of Runx2 during development as well as the post-translational regulation of Runx2 through modification by phosphorylation, ubiquitination, and acetylation.

Indexed as

AcetylationBone and BonesBone DevelopmentCartilageChondrocytesCore Binding Factor Alpha 1 SubunitHumansOdontogenesisOsteoblastsPhosphorylationProtein BiosynthesisProtein Processing, Post-TranslationalTranscription, GeneticUbiquitinationCore Binding Factor Alpha 1 SubunitRUNX2 protein, human

Identifiers

PMID19734454
PMCPMC2883617
OpenAlexW1996842235

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.