ArticleJournal of experimental botany2009
Insect peptide metchnikowin confers on barley a selective capacity for resistance to fungal ascomycetes pathogens.
Article in Journal of experimental botany, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 79 citations in OpenAlex.
- Proline-Rich Antimicrobial Peptides from Invertebrates.Molecules (Basel, Switzerland) · 2024Review
- Heterologous Production of Antimicrobial Peptides: Notes to Consider.The protein journal · 2024Article
- Insect Antimicrobial Peptides: Advancements, Enhancements and New Challenges.Antibiotics (Basel, Switzerland) · 2023Review
- Biotechnological Insights on the Expression and Production of Antimicrobial Peptides in Plants.Molecules (Basel, Switzerland) · 2021Review
- Proline-Rich Antimicrobial Peptides in Medicinal Maggots ofFrontiers in pharmacology · 2020Article
- The Drosophila melanogaster antimicrobial peptides Mtk-1 and Mtk-2 are active against the malarial parasite Plasmodium falciparum.Parasitology research · 2019Article
- Tryptophan-Rich and Proline-Rich Antimicrobial Peptides.Molecules (Basel, Switzerland) · 2018Review
- The entomopathogenic fungus Metarhizium robertsii communicates with the insect host Galleria mellonella during infection.Virulence · 2018Article
- Article
- The selective antifungal activity of Drosophila melanogaster metchnikowin reflects the species-dependent inhibition of succinate-coenzyme Q reductase.Scientific reports · 2017Article
- Heterologous expression of abaecin peptide from Apis mellifera in Pichia pastoris.Microbial cell factories · 2017Article
- Article
- Isolation and Purification of an Antibacterial Protein from Immune Induced Haemolymph of American Cockroach,Journal of arthropod-borne diseases · 2016Article
- Tissue expression and antibacterial activity of host defense peptides in chicken.BMC veterinary research · 2016Article
- Characterization and regulation of expression of an antifungal peptide from hemolymph of an insect, Manduca sexta.Developmental and comparative immunology · 2016Article
- Diversity, evolution and medical applications of insect antimicrobial peptides.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- Cooperative interaction of antimicrobial peptides with the interrelated immune pathways in plants.Molecular plant pathology · 2016Review
- Short antimicrobial peptides as cosmetic ingredients to deter dermatological pathogens.Applied microbiology and biotechnology · 2015Review
- Thanatin confers partial resistance against aflatoxigenic fungi in maize (Zea mays).Transgenic research · 2015Article
- Insect antimicrobial peptides show potentiating functional interactions against Gram-negative bacteria.Proceedings. Biological sciences · 2015Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The potential of metchnikowin, a 26-amino acid residue proline-rich antimicrobial peptide synthesized in the fat body of Drosophila melanogaster was explored to engineer disease resistance in barley against devastating fungal plant pathogens. The synthetic peptide caused strong in vitro growth inhibition (IC(50) value approximately 1 muM) of the pathogenic fungus Fusarium graminearum. Transgenic barley expressing the metchnikowin gene in its 52-amino acid pre-pro-peptide form under the control of the inducible mannopine synthase (mas) gene promoter from the T(i) plasmid of Agrobacterium tumefaciens displayed enhanced resistance to powdery mildew as well as Fusarium head blight and root rot. In response to these pathogens, metchnikowin accumulated in plant apoplastic space, specifying that the insect signal peptide is functional in monocotyledons. In vitro and in vivo tests revealed that the peptide is markedly effective against fungal pathogens of the phylum Ascomycota but, clearly, less active against Basidiomycota fungi. Importantly, germination of the mutualistic basidiomycete mycorrhizal fungus Piriformospora indica was affected only at concentrations beyond 50 muM. These results suggest that antifungal peptides from insects are a valuable source for crop plant improvements and their differential activities toward different phyla of fungi denote a capacity for insect peptides to be used as selective measures on specific plant diseases.
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