ArticleThe Journal of biological chemistry2009
Speckled-like pattern in the germinal center (SLIP-GC), a nuclear GTPase expressed in activation-induced deaminase-expressing lymphomas and germinal center B cells.
Article in The Journal of biological chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 16 citations in OpenAlex.
- Multiple Horizontal Transfers of Immune Genes Between Distantly Related Teleost Fishes.Molecular biology and evolution · 2025Article
- Mitf regulates gene expression networks implicated in B cell homeostasis, germinal center responses, and tolerance.Frontiers in immunology · 2024Article
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- Re-testing reported significant SNPs related to suicide in a historical high -risk isolated population from north east India.Hereditas · 2020Article
- Quantitative trait loci and genes associated with salmonid alphavirus load in Atlantic salmon: implications for pancreas disease resistance and tolerance.Scientific reports · 2020Article
- Response of the Salmon Heart Transcriptome to Pancreas Disease: Differences Between High- and Low-Ranking Families for Resistance.Scientific reports · 2020Article
- Selective Histone Deacetylase 6 Inhibition Normalizes B Cell Activation and Germinal Center Formation in a Model of Systemic Lupus Erythematosus.Frontiers in immunology · 2019Article
- Humanized Immunoglobulin Mice: Models for HIV Vaccine Testing and Studying the Broadly Neutralizing Antibody Problem.Advances in immunology · 2017Review
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- Convergent transcription at intragenic super-enhancers targets AID-initiated genomic instability.Cell · 2014Article
- Ontology based molecular signatures for immune cell types via gene expression analysis.BMC bioinformatics · 2013Article
- Altered pattern of immunoglobulin hypermutation in mice deficient in Slip-GC protein.The Journal of biological chemistry · 2012Article
- Super-SILAC allows classification of diffuse large B-cell lymphoma subtypes by their protein expression profiles.Molecular & cellular proteomics : MCP · 2012Article
- Identification and characterization of a leucine-rich repeat kinase 2 (LRRK2) consensus phosphorylation motif.PloS one · 2010Article
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
We identified a novel GTPase, SLIP-GC, with expression limited to a few tissues, in particular germinal center B cells. It lacks homology to any known proteins, indicating that it may belong to a novel family of GTPases. SLIP-GC is expressed in germinal center B cells and in lymphomas derived from germinal center B cells such as large diffuse B cell lymphomas. In cell lines, SLIP-GC is expressed in lymphomas that express activation-induced deaminase (AID) and that likely undergo somatic hypermutation. SLIP-GC is a nuclear protein, and it localizes to replication factories. Reduction of SLIP-GC levels in the Burkitt lymphoma cell line Raji and in non-Hodgkin lymphoma cell lines resulted in an increase in DNA breaks and apoptosis that was AID-dependent, as simultaneous reduction of AID abrogated the deleterious effects of SLIP-GC reduction. These results strongly suggest that SLIP-GC is a replication-related protein in germinal center B cells whose reduction is toxic to cells through an AID-dependent mechanism.
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