Trial reportSchizophrenia research2009
Structural magnetic resonance imaging predictors of responsiveness to cognitive behaviour therapy in psychosis.
Trial report in Schizophrenia research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 31 citations in OpenAlex.
- Sensorimotor gating and clinical outcome following cognitive behaviour therapy for psychosis.Schizophrenia research · 2012Trial
- Coping styles predict responsiveness to cognitive behaviour therapy in psychosis.Psychiatry research · 2011Trial
- Abnormal network homogeneity of default-mode network and its relationships with clinical symptoms in antipsychotic-naïve first-diagnosis schizophrenia.Frontiers in neuroscience · 2022Article
- Pituitary volume reduction in schizophrenia following cognitive behavioural therapy.Schizophrenia research · 2018Article
- Using fMRI and machine learning to predict symptom improvement following cognitive behavioural therapy for psychosis.NeuroImage. Clinical · 2018Article
- How can neuroimaging facilitate the diagnosis and stratification of patients with psychosis?European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2015Review
- Orbitofrontal cortex, emotional decision-making and response to cognitive behavioural therapy for psychosis.Psychiatry research · 2015Article
- Prediction as a humanitarian and pragmatic contribution from human cognitive neuroscience.Neuron · 2015Review
- Neuroimaging for psychotherapy research: current trends.Psychotherapy research : journal of the Society for Psychotherapy Research · 2015Review
- Cerebral white matter abnormalities and their associations with negative but not positive symptoms of schizophrenia.Psychiatry research · 2014Article
- Cognitive impairments in alcohol-dependent subjects.Frontiers in psychiatry · 2014Review
- Dissociable morphometric differences of the inferior parietal lobule in schizophrenia.European archives of psychiatry and clinical neuroscience · 2012Article
- Are we studying and treating schizophrenia correctly?Schizophrenia research · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundResponsiveness to cognitive behaviour therapy (CBT) in psychosis may have a neurological basis. This study aimed to determine whether improvement in symptoms following CBT for psychosis (CBTp) in people with schizophrenia is positively associated with pre-therapy grey matter volume in brain regions involved in cognitive processing.
methodsSixty outpatients stable on medication with at least one distressing symptom of schizophrenia and willing to receive CBTp in addition to their standard care (SC), and 25 healthy participants underwent magnetic resonance imaging. Subsequently, 30 patients received CBTp (CBTp+SC; 25 completers) for 6-8 months and 30 continued with their standard care (SC; 19 completers). Symptoms in all patients were assessed (blindly) at entry and follow-up.
resultsThe CBTp+SC and SC groups did not differ clinically at baseline, and only the CBTp+SC group showed improved symptoms at follow-up. Severity of baseline symptoms was not associated with CBTp responsiveness. Reduction with CBTp in positive symptoms was associated with greater right cerebellum (lobule VII) grey matter volume, in negative symptoms with left precentral gyrus and right inferior parietal lobule grey matter volumes, and in general psychopathology with greater right superior temporal gyrus, cuneus and cerebellum (Crus I) grey matter volumes. Grey matter volume in these brain areas did not correlate with the severity of baseline symptoms.
conclusionGrey matter volume of the frontal, temporal, parietal and cerebellar areas that are known to be involved in the co-ordination of mental activity, cognitive flexibility, and verbal learning and memory predict responsiveness to CBTp in patients with psychosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.