ArticleAmerican journal of obstetrics and gynecology2009
Polymorphisms in thrombophilia and renin-angiotensin system pathways, preterm delivery, and evidence of placental hemorrhage.
Article in American journal of obstetrics and gynecology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Global and population-specific association of MTHFR polymorphisms with preterm birth risk: a consolidated analysis of 44 studies.BMC pregnancy and childbirth · 2025Pooled it
- Article
- Abruptio placentae risk and genetic variations in mitochondrial biogenesis and oxidative phosphorylation: replication of a candidate gene association study.American journal of obstetrics and gynecology · 2018Article
- Spontaneous preterm birth: advances toward the discovery of genetic predisposition.American journal of obstetrics and gynecology · 2018Review
- Spontaneous preterm birth and single nucleotide gene polymorphisms: a recent update.BMC genomics · 2016Review
- Placental lesions associated with acute atherosis.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2015Article
- Article
- Prevalence of 1691G>A FV mutation in females from Bosnia and Herzegovina--a preliminary report.Bosnian journal of basic medical sciences · 2013Article
- Late-preterm birth by delivery circumstance and its association with parent-reported attention problems in childhood.Journal of developmental and behavioral pediatrics : JDBP · 2012Article
- Maternal lipids at mid-pregnancy and the risk of preterm delivery.Acta obstetricia et gynecologica Scandinavica · 2012Article
- California Very Preterm Birth Study: design and characteristics of the population- and biospecimen bank-based nested case-control study.Paediatric and perinatal epidemiology · 2012Article
- A genome-wide association study of variations in maternal cardiometabolic genes and risk of placental abruption.International journal of molecular epidemiology and genetics · 2012Article
- Biological indicators of the in-utero environment and their association with birth weight for gestational age.Journal of developmental origins of health and disease · 2011Article
- Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes.American journal of obstetrics and gynecology · 2010Article
- Evidence of placental haemorrhage and preterm delivery.BJOG : an international journal of obstetrics and gynaecology · 2010Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveThe purpose of this study was to analyze functional polymorphisms in candidate genes (methylenetetrahydrofolate reductase [MTHFR]677C>T, MTHFR1298A>C, factor 5 1691G>A [FVL], and angiotensinogen (AGT)-6G>A) in relation to a hypothesized placental hemorrhage pathway to preterm delivery (PTD). STUDY
designWe assessed maternal genotypes, pregnancy outcomes, and placental pathologic evidence among 560 white and 399 black women who were recruited at mid trimester into a prospective cohort study (1998-2004). Odds of dominant genotypes were calculated for PTDs with (n = 56) or without (n = 177) evidence of placental hemorrhage (referent = term) with the use of race-stratified polytomous logistic regression models.
resultsAmong white women, FVL GA/AA and AGT(-6) GA/AA were both associated with hemorrhage-related PTDs (odds ratio [OR], 4.8; 95% confidence interval [CI], 1.6-14.2 and OR, 3.8; 95% CI, 1.3-10.5, respectively), but not other PTDs (ORs, 1.2 and 0.9, respectively). FVL GA/AA was associated with placental abruption (OR, 5.8; 95% CI, 1.1-30) among white women. All results were null for MTHFR genotypes.
conclusionFVL and AGT variant genotypes were associated specifically with hemorrhage-related PTDs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.