ArticleJournal of magnetic resonance (San Diego, Calif. : 1997)2009
A Modified Alderman-Grant Coil makes possible an efficient cross-coil probe for high field solid-state NMR of lossy biological samples.
Article in Journal of magnetic resonance (San Diego, Calif. : 1997), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
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- Interactions of SARS-CoV-2 envelope protein with amilorides correlate with antiviral activity.PLoS pathogens · 2021Article
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- 3D-printed dissolvable inserts for efficient and customizable fabrication of NMR transceiver coils.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2019Article
- Advances in instrumentation and methodology for solid-state NMR of biological assemblies.Journal of structural biology · 2019Review
- Control of Transmembrane Helix Dynamics by Interfacial Tryptophan Residues.Biophysical journal · 2018Article
- Design and construction of a quadruple-resonance MAS NMR probe for investigation of extensively deuterated biomolecules.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2017Article
- NMR spectroscopy up to 35.2T using a series-connected hybrid magnet.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2017Article
- Spatial reorientation experiments for NMR of solids and partially oriented liquids.Progress in nuclear magnetic resonance spectroscopy · 2015Review
- Orthogonal resonators for pulse in vivo electron paramagnetic imaging at 250 MHz.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2014Article
- Covariance spectroscopy in high-resolution multi-dimensional solid-state NMR.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2014Article
- Sampling scheme and compressed sensing applied to solid-state NMR spectroscopy.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2013Article
- Experiments optimized for magic angle spinning and oriented sample solid-state NMR of proteins.The journal of physical chemistry. B · 2013Article
- Improved 1H amide resonance line narrowing in oriented sample solid-state NMR of membrane proteins in phospholipid bilayers.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2012Article
- Optimization of purification and refolding of the human chemokine receptor CXCR1 improves the stability of proteoliposomes for structure determination.Biochimica et biophysica acta · 2012Article
- Interactions of interleukin-8 with the human chemokine receptor CXCR1 in phospholipid bilayers by NMR spectroscopy.Journal of molecular biology · 2011Article
- Local and global dynamics of the G protein-coupled receptor CXCR1.Biochemistry · 2011Article
- Triton X-100 as the "short-chain lipid" improves the magnetic alignment and stability of membrane proteins in phosphatidylcholine bilayers for oriented-sample solid-state NMR spectroscopy.Journal of the American Chemical Society · 2010Article
- 1H-13C separated local field spectroscopy of uniformly 13C labeled peptides and proteins.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2010Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
The design, construction, and performance of a cross-coil double-resonance probe for solid-state NMR experiments on lossy biological samples at high magnetic fields are described. The outer coil is a Modified Alderman-Grant Coil (MAGC) tuned to the (1)H frequency. The inner coil consists of a multi-turn solenoid coil that produces a B(1) field orthogonal to that of the outer coil. This results in a compact nested cross-coil pair with the inner solenoid coil tuned to the low frequency detection channel. This design has several advantages over multiple-tuned solenoid coil probes, since RF heating from the (1)H channel is substantially reduced, it can be tuned for samples with a wide range of dielectric constants, and the simplified circuit design and high inductance inner coil provides excellent sensitivity. The utility of this probe is demonstrated on two electrically lossy samples of membrane proteins in phospholipid bilayers (bicelles) that are particularly difficult for conventional NMR probes. The 72-residue polypeptide embedding the transmembrane helices 3 and 4 of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) (residues 194-241) requires a high salt concentration in order to be successfully reconstituted in phospholipid bicelles. A second application is to paramagnetic relaxation enhancement applied to the membrane-bound form of Pf1 coat protein in phospholipid bicelles where the resistance to sample heating enables high duty cycle solid-state NMR experiments to be performed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.