Evidence map›Paper›PMID 19732789›Full record

ReviewMolecular aspects of medicine2009

Receptors of anthrax toxin and cell entry.

Gisou van der Goot, John A T Young

Abstract readReview
In one paragraph

Review in Molecular aspects of medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Targeting the Inside of Cells with Biologicals: Toxin Routes in a Therapeutic Context.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2023
    Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Inhibitors of the Metalloproteinase Anthrax Lethal Factor.Current topics in medicinal chemistry · 2016
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Gisou van der GootGlobal Health Institute, Ecole Polytechnique Fédérale de Lausanne, SV-AI Extension, Station 15, 1015 Lausanne, Switzerland. gisou.vandergoot@epfl.ch
John A T Young

Funding

Receptor Decoy Inhibitor of Anthrax ToxinR01AI076852 · NIAID · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI MANCHESTER, MARIANNE, YOUNG, JOHN A T · 2008 to 2012
$2.4M
Cellular factors in gammaretrovirus replicationR01AI072645 · NIAID · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI YOUNG, JOHN A T · 2007 to 2011
$2.2M
NIAID NIH HHS R01 AI072645NIAID NIH HHS R01 AI076852
6 · The paper itself

Abstract

Anthrax toxin-receptor interactions are critical for toxin delivery to the host cell cytoplasm. This review summarizes what is known about the molecular details of the protective antigen (PA) toxin subunit interaction with either the ANTXR1 and ANTXR2 cellular receptors, and how receptor-type can dictate the low pH threshold of PA pore formation. The roles played by cellular factors in regulating the endocytosis of toxin-receptor complexes is also discussed.

Indexed as

Adaptor Proteins, Signal TransducingAnimalsAntigens, BacterialBacillus anthracisBacterial ToxinsEndocytosisEndosomesGTPase-Activating ProteinsHumansHydrogen-Ion ConcentrationLow Density Lipoprotein Receptor-Related Protein-6Models, MolecularProtein ConformationProtein SubunitsReceptors, LDLReceptors, PeptideAdaptor Proteins, Signal Transducinganthrax toxinanthrax toxin receptorsAntigens, BacterialARAP3 protein, humanBacterial ToxinsGTPase-Activating ProteinsLow Density Lipoprotein Receptor-Related Protein-6LRP6 protein, humanProtein SubunitsReceptors, LDLReceptors, Peptide

Identifiers

PMID19732789
PMCPMC2783407

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.