Evidence map›Paper›PMID 19732612›Full record

ReviewClinics in perinatology2009

Cerebral blood flow and metabolism in the developing fetus.

Adré J du Plessis

Abstract readReview
In one paragraph

Review in Clinics in perinatology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Fetal Cerebral Blood Flow (Dys)autoregulation.Diagnostics (Basel, Switzerland) · 2025
    Review
  5. Review
  6. Small animal PET with spontaneous inhalation ofJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Article
  7. Placenta-Heart-Brain Connection in Congenital Heart Disease.Journal of the American Heart Association · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Fetal Cerebrovascular Maturation: Effects of Hypoxia.Seminars in pediatric neurology · 2018
    Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Adré J du PlessisHarvard Medical School, Boston, MA, USA. duplessis@childrens.harvard.edu

Funding

Quantitation of Insult and Injury to the Preterm BrainK24NS057568 · NINDS · CHILDREN'S RESEARCH INSTITUTE · PI DU PLESSIS, ADRE JACQUES · 2007 to 2011
$641k
Continuous Monitoring for Cerebral Pressure-Passivity in Premature InfantsR21HD056009 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI DU PLESSIS, ADRE JACQUES · 2007 to 2008
$460k
NICHD NIH HHS R21 HD056009NICHD NIH HHS R21HD056009NINDS NIH HHS K24 NS057568NINDS NIH HHS K24NS057568
6 · The paper itself

Abstract

The inaccessibility of the human fetal brain to studies of perfusion and metabolism has impeded progress in the understanding of the normal and abnormal systems of oxygen substrate supply and demand. Consequently, current understanding is based on studies in fetal animals or in the premature infant (ex utero fetus), neither of which is ideal. Despite promising developments in fetal magnetic resonance imaging (MRI) and Doppler ultrasound, major advances in fetal neurodiagnostics will be required before rational and truly informed brainoriented care of the fetus becomes feasible.

Indexed as

AnimalsBrainCerebrovascular CirculationEnergy MetabolismFemaleFetusHumansHypoxia-Ischemia, BrainPlacentaPregnancy

Identifiers

PMID19732612
PMCPMC13093913

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.