ArticleFEMS yeast research2009
Widespread occurrence of chromosomal aneuploidy following the routine production of Candida albicans mutants.
Article in FEMS yeast research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Review
- Strain background interacts with chromosome 7 aneuploidy to determine commensal and virulence phenotypes in Candida albicans.PLoS genetics · 2025Article
- Profiling inflammatory outcomes ofmBio · 2024Article
- Strain background ofMicrobiology (Reading, England) · 2024Article
- CRISPR-Cas9 Editing Induces Loss of Heterozygosity in the Pathogenic Yeast Candida parapsilosis.mSphere · 2022Article
- Aneuploidy Underlies Tolerance and Cross-Tolerance to Drugs in Candida parapsilosis.Microbiology spectrum · 2021Article
- Population genomics of the pathogenic yeast Candida tropicalis identifies hybrid isolates in environmental samples.PLoS pathogens · 2021Article
- Use of CRISPR-Cas9 To Target Homologous Recombination Limits Transformation-Induced Genomic Changes in Candida albicans.mSphere · 2020Article
- Virulence phenotypes result from interactions between pathogen ploidy and genetic background.Ecology and evolution · 2020Article
- The Impact of Gene Dosage and Heterozygosity on The Diploid PathobiontJournal of fungi (Basel, Switzerland) · 2019Review
- Mechanisms of genome evolution in Candida albicans.Current opinion in microbiology · 2019Review
- Susceptibility to Medium-Chain Fatty Acids Is Associated with Trisomy of Chromosome 7 inmSphere · 2019Article
- A natural histone H2A variant lacking the Bub1 phosphorylation site and regulated depletion of centromeric histone CENP-A foster evolvability in Candida albicans.PLoS biology · 2019Article
- Global analysis of mutations driving microevolution of a heterozygous diploid fungal pathogen.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Chemogenomic Profiling of the Fungal Pathogen Candida albicans.Antimicrobial agents and chemotherapy · 2018Article
- An Update onFrontiers in microbiology · 2017Review
- Phenotypic Consequences of a Spontaneous Loss of Heterozygosity in a Common Laboratory Strain of Candida albicans.Genetics · 2016Article
- Parasexual Ploidy Reduction Drives Population Heterogeneity Through Random and Transient Aneuploidy in Candida albicans.Genetics · 2015Article
- Microevolution of Candida albicans in macrophages restores filamentation in a nonfilamentous mutant.PLoS genetics · 2014Article
- Adaptation of Candida albicans to growth on sorbose via monosomy of chromosome 5 accompanied by duplication of another chromosome carrying a gene responsible for sorbose utilization.FEMS yeast research · 2014Article
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9 authors.
Funding
Abstract
It has come to our attention that approximately 35% of >100 published microarray datasets, where transcript levels were compared between two different strains, exhibit some form of chromosome-specific bias. While some of these arose from the use of strains whose aneuploidies were not known at the time, in a worrisome number of cases the recombinant strains have acquired additional aneuploidies that were not initially present in the parental strain. The aneuploidies often affected a different chromosome than the one harboring the insertion site. The affected strains originated from either CAI-4, RM1000, BWP17 or SN95 and were produced through a variety of strategies. These observations suggest that aneuploidies frequently occur during the production of recombinant strains and have an effect on global transcript profiles outside of the afflicted chromosome(s), thus raising the possibility of unintended phenotypic consequences. Thus, we propose that all Candida albicans mutants and strains should be tested for aneuploidy before being used in further studies. To this end, we describe a new rapid testing method, based on a multiplex quantitative PCR assay, that produces eight bands of distinct sizes from either the left or right arms of each C. albicans chromosome.
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