ArticleAging cell2009
Calorie restriction reduces rDNA recombination independently of rDNA silencing.
Article in Aging cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 46 citations in OpenAlex.
- Article
- Compensatory evolution to DNA replication stress is robust to nutrient availability.Molecular systems biology · 2025Article
- Proteomic analysis of dietary restriction in yeast reveals a role for Hsp26 in replicative lifespan extension.The Biochemical journal · 2021Article
- Review
- Metabolic regulation of telomere silencing by SESAME complex-catalyzed H3T11 phosphorylation.Nature communications · 2021Article
- Review
- Depletion of Limiting rDNA Structural Complexes Triggers Chromosomal Instability and Replicative Aging ofGenetics · 2019Article
- Loss of Nat4 and its associated histone H4 N-terminal acetylation mediates calorie restriction-induced longevity.EMBO reports · 2016Article
- The Nuts and Bolts of Transcriptionally Silent Chromatin in Saccharomyces cerevisiae.Genetics · 2016Review
- Depletion of histone N-terminal-acetyltransferase Naa40 induces p53-independent apoptosis in colorectal cancer cells via the mitochondrial pathway.Apoptosis : an international journal on programmed cell death · 2016Article
- Dietary restriction, mitochondrial function and aging: from yeast to humans.Biochimica et biophysica acta · 2015Review
- A budding yeast's perspective on aging: the shape I'm in.Experimental biology and medicine (Maywood, N.J.) · 2015Review
- The anaphase promoting complex regulates yeast lifespan and rDNA stability by targeting Fob1 for degradation.Genetics · 2014Article
- Yeast sirtuins and the regulation of aging.FEMS yeast research · 2014Review
- Resveratrol and diabetes.The review of diabetic studies : RDS · 2013Review
- N-alpha-terminal acetylation of histone H4 regulates arginine methylation and ribosomal DNA silencing.PLoS genetics · 2013Article
- Replicative and chronological aging in Saccharomyces cerevisiae.Cell metabolism · 2012Review
- Global heterochromatin loss: a unifying theory of aging?Epigenetics · 2012Article
- Diet and aging.Oxidative medicine and cellular longevity · 2012Review
- NMR structure of Hsp12, a protein induced by and required for dietary restriction-induced lifespan extension in yeast.PloS one · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Calorie restriction (CR) extends lifespan in yeast, worms, flies and mammals, suggesting that it acts via a conserved mechanism. In yeast, activation of the NAD-dependent histone deacetylase, Sir2, by CR is thought to increase silencing at the ribosomal DNA, thereby reducing the recombination-induced generation of extrachromosomal rDNA circles, hence increasing replicative lifespan. Although accumulation of extrachromosomal rDNA circles is specific to yeast aging, it is thought that Sirtuin activation represents a conserved longevity mechanism through which the beneficial effects of CR are mediated in various species. We show here that growing yeast on 0.05 or 0.5% glucose (severe and moderate CR, respectively) does not increase silencing at either sub-telomeric or rDNA loci compared with standard (2% glucose) media. Furthermore, rDNA silencing was unaffected in the hxk2Delta, sch9Delta and tor1Delta genetic mimics of CR, but inhibited by FOB1 deletion. All these interventions extend lifespan in multiple yeast backgrounds, revealing a poor correlation between rDNA silencing and longevity. In contrast, CR and deletion of the FOB1, HXK2, SCH9 and TOR1 genes, all significantly reduced rDNA recombination. This silencing-independent mechanism for suppressing rDNA recombination may therefore contribute to CR-mediated lifespan extension.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.