ArticleThe Journal of comparative neurology2009
Chronic stress-induced neurotransmitter plasticity in the PVN.
Article in The Journal of comparative neurology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
81 citing papers in PubMed, 143 citations in OpenAlex.
- Social subordination produces distinct stress-related phenotypes in female rhesus monkeys.Psychoneuroendocrinology · 2012Trial
- HPA/HPG axes dysfunction: assessing the interrelations between diminished ovarian reserve and mental health.Journal of ovarian research · 2026Review
- Anxiolytic and Antidepressant Effects of Organic Polysulfide, Dimethyl Trisulfide Are Partly Mediated by the Transient Receptor Potential Ankyrin 1 Ion Channel in Mice.Pharmaceutics · 2025Article
- Modulating reward and aversion: Insights into addiction from the paraventricular nucleus.CNS neuroscience & therapeutics · 2024Review
- Salt-inducible kinase 1-CREB-regulated transcription coactivator 1 signalling in the paraventricular nucleus of the hypothalamus plays a role in depression by regulating the hypothalamic-pituitary-adrenal axis.Molecular psychiatry · 2024Article
- Chronically stressed male and female mice show a similar peripheral and central pro-inflammatory profile after an immune challenge.PloS one · 2024Article
- Chemogenetic activation of CRF neurons as a model of chronic stress produces sex-specific physiological and behavioral effects.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Hindbrain Adrenergic/Noradrenergic Control of Integrated Endocrine and Autonomic Stress Responses.Endocrinology · 2023Review
- Impact and Role of Hypothalamic Corticotropin Releasing Hormone Neurons in Withdrawal from Chronic Alcohol Consumption in Female and Male Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Regulation of corticotropin-releasing hormone neuronal network activity by noradrenergic stress signals.The Journal of physiology · 2022Article
- The metabolic stress response: Adaptation to acute-, repeated- and chronic challenges in mice.iScience · 2022Article
- Involvement of the Dorsal Vagal Complex in Alcohol-Related Behaviors.Frontiers in behavioral neuroscience · 2022Review
- Dysfunction of the hypothalamic‑pituitary‑adrenal axis in male rat offspring with prenatal food restriction: Fetal programming of hypothalamic hyperexcitability and poor hippocampal feedback.Molecular medicine reports · 2022Article
- Chronic Restraint Stress Decreases the Excitability of Hypothalamic POMC Neuron and Increases Food Intake.Experimental neurobiology · 2021Article
- BNSTFrontiers in pharmacology · 2021Article
- StandardizedAntioxidants (Basel, Switzerland) · 2020Article
- Effects of long-lasting social isolation and re-socialization on cognitive performance and brain activity: a longitudinal study in Octodon degus.Scientific reports · 2020Article
- Insulin synthesized in the paraventricular nucleus of the hypothalamus regulates pituitary growth hormone production.JCI insight · 2020Article
- Astrocytes Amplify Neuronal Dendritic Volume Transmission Stimulated by Norepinephrine.Cell reports · 2019Article
- Chronic stress dampens excitatory synaptic gain in the paraventricular nucleus of the hypothalamus.The Journal of physiology · 2018Article
21 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Chronic stress precipitates pronounced enhancement of central stress excitability, marked by sensitization of hypothalamic-pituitary-adrenocortical (HPA) axis responses and increased adrenocorticotropic hormone (ACTH) secretagogue biosynthesis in the paraventricular nucleus of the hypothalamus (PVN). Chronic stress-induced enhancement of HPA axis excitability predicts increased excitatory and/or decreased inhibitory innervation of the parvocellular PVN. We tested this hypothesis by evaluating chronic variable stress (CVS)-induced changes in total (synaptophysin), glutamatergic (VGluT2), GABAergic (GAD65), and noradrenergic (DBH) terminal immunoreactivity on PVN parvocellular neurons using immunofluorescence confocal microscopy. CVS increased the total PVN bouton immunoreactivity as well as the number of glutamatergic and noradrenergic immunoreactive boutons in apposition to both the corticotropin-releasing hormone (CRH)-immunoreactive cell bodies and dendrites within the parvocellular PVN. However, the number of GABAergic-immunoreactive boutons in the PVN was unchanged. CVS did not alter CRH median eminence immunoreactivity, indicating that CVS does not enhance CRH storage within the median eminence. Taken together, the data are consistent with a role for both glutamate and norepinephrine in chronic stress enhancement of HPA axis excitability. These changes could lead to an enhanced capacity for excitation in these neurons, contributing to chronic stress-induced hyperreactivity of stress effector systems in the brain.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.