ReviewCell stress & chaperones2010
Caught with their PAMPs down? The extracellular signalling actions of molecular chaperones are not due to microbial contaminants.
Review in Cell stress & chaperones, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 104 citations in OpenAlex.
- Role of heat shock protein and cytokine expression as markers of clinical outcomes with glutamine-supplemented parenteral nutrition in surgical ICU patients.Clinical nutrition (Edinburgh, Scotland) · 2020Trial
- Intracellular heat shock protein-70 negatively regulates TLR4 signaling in the newborn intestinal epithelium.Journal of immunology (Baltimore, Md. : 1950) · 2012Trial
- Exogenous heat shock proteins HSPA1A and HSPB1 regulate TNF-α, IL-1β and IL-10 secretion from monocytic cells.FEBS open bio · 2023Article
- Organismal Roles of Hsp90.Biomolecules · 2023Review
- Molecular Chaperone Receptors: An Update.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Function and Fiber-Type Specific Distribution of Hsp60 and αB-Crystallin in Skeletal Muscles: Role of Physical Exercise.Biology · 2021Review
- The Biophysical Interaction of the Danger-Associated Molecular Pattern (DAMP) Calreticulin with the Pattern-Associated Molecular Pattern (PAMP) Lipopolysaccharide.International journal of molecular sciences · 2019Article
- Heat shock proteins as modulators and therapeutic targets of chronic disease: an integrated perspective.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Article
- Extracellular cell stress (heat shock) proteins-immune responses and disease: an overview.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- Molecular Chaperone Receptors.Methods in molecular biology (Clifton, N.J.) · 2018Article
- The Helicobacter pylori cytotoxin CagA is essential for suppressing host heat shock protein expression.Cell stress & chaperones · 2016Article
- The human HSP70 family of chaperones: where do we stand?Cell stress & chaperones · 2016Review
- Skeletal muscle Heat shock protein 60 increases after endurance training and induces peroxisome proliferator-activated receptor gamma coactivator 1 α1 expression.Scientific reports · 2016Article
- Does Hsp60 Provide a Link between Mitochondrial Stress and Inflammation in Diabetes Mellitus?Journal of diabetes research · 2016Review
- Intrathecal heat shock protein 60 mediates neurodegeneration and demyelination in the CNS through a TLR4- and MyD88-dependent pathway.Molecular neurodegeneration · 2015Article
- Chaperoned amyloid proteins for immune manipulation: α-Synuclein/Hsp70 shifts immunity toward a modulatory phenotype.Immunity, inflammation and disease · 2014Article
- Hsp10 nuclear localization and changes in lung cells response to cigarette smoke suggest novel roles for this chaperonin.Open biology · 2014Article
- The impact of single and pairwise Toll-like receptor activation on neuroinflammation and neurodegeneration.Journal of neuroinflammation · 2014Article
- Monocyte cytokine synthesis in response to extracellular cell stress proteins suggests these proteins exhibit network behaviour.Cell stress & chaperones · 2014Article
- The Endoplasmic Reticulum Chaperone GRP170: From Immunobiology to Cancer Therapeutics.Frontiers in oncology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 7 institutions in 4 countries.
Funding
Abstract
In recent years, it has been hypothesised that a new signalling system may exist in vertebrates in which secreted molecular chaperones form a dynamic continuum between the cellular stress response and corresponding homeostatic physiological mechanisms. This hypothesis seems to be supported by the finding that many molecular chaperones are released from cells and act as extracellular signals for a range of cells. However, this nascent field of biological research seems to suffer from an excessive criticism that the biological activities of molecular chaperones are due to undefined components of the microbial expression hosts used to generate recombinant versions of these proteins. In this article, a number of the proponents of the cell signalling actions of molecular chaperones take this criticism head-on. They show that sufficient evidence exists to support fully the hypothesis that molecular chaperones have cell-cell signalling actions that are likely to be part of the homeostatic mechanism of the vertebrate.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.