ArticleJournal of biomolecular NMR2010
Overcoming the solubility limit with solubility-enhancement tags: successful applications in biomolecular NMR studies.
Article in Journal of biomolecular NMR, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 85 citations in OpenAlex.
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- Synthetic intrinsically disordered protein fusion tags that enhance protein solubility.Nature communications · 2024Article
- MATR3 is an endogenous inhibitor of DUX4 in FSHD muscular dystrophy.Cell reports · 2023Article
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- An Intrinsically Disordered Peptide Tag that Confers an Unusual Solubility to Aggregation-Prone Proteins.Applied and environmental microbiology · 2022Article
- An engineered construct of cFLIP provides insight into DED1 structure and interactions.Structure (London, England : 1993) · 2022Article
- Protein Expression Optimization Strategies in E. coli: A Tailored Approach in Strain Selection and Parallelizing Expression Conditions.Methods in molecular biology (Clifton, N.J.) · 2022Article
- High-resolution analysis of the conformational transition of pro-apoptotic Bak at the lipid membrane.The EMBO journal · 2021Article
- Thermodynamic stability of hnRNP A1 low complexity domain revealed by high-pressure NMR.Proteins · 2021Article
- Efficient Unnatural Protein Production by Pyrrolysyl-tRNA Synthetase With Genetically Fused Solubility Tags.Frontiers in bioengineering and biotechnology · 2021Article
- Efficient detection of eukaryotic calcium-sensing receptor (CaSR) by polyclonal antibody against prokaryotic expressed truncated CaSR.Molecular biology reports · 2020Article
- Proline-rich domain of human ALIX contains multiple TSG101-UEV interaction sites and forms phosphorylation-mediated reversible amyloids.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- The Measles Virus V Protein Binding Site to STAT2 Overlaps That of IRF9.Journal of virology · 2020Article
- Cooperative Regulation ofMicroorganisms · 2020Article
- The two paralogous kiwellin proteins KWL1 and KWL1-b from maize are structurally related and have overlapping functions in plant defense.The Journal of biological chemistry · 2020Article
- Heme interaction of the intrinsically disordered N-terminal peptide segment of human cystathionine-β-synthase.Scientific reports · 2018Article
- Distinct activation modes of the Relaxin Family Peptide Receptor 2 in response to insulin-like peptide 3 and relaxin.Scientific reports · 2017Article
- Probing Receptor Specificity by Sampling the Conformational Space of the Insulin-like Growth Factor II C-domain.The Journal of biological chemistry · 2016Article
- Identification of the first small-molecule inhibitor of the REV7 DNA repair protein interaction.Bioorganic & medicinal chemistry · 2016Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Although the rapid progress of NMR technology has significantly expanded the range of NMR-trackable systems, preparation of NMR-suitable samples that are highly soluble and stable remains a bottleneck for studies of many biological systems. The application of solubility-enhancement tags (SETs) has been highly effective in overcoming solubility and sample stability issues and has enabled structural studies of important biological systems previously deemed unapproachable by solution NMR techniques. In this review, we provide a brief survey of the development and successful applications of the SET strategy in biomolecular NMR.We also comment on the criteria for choosing optimal SETs, such as for differently charged target proteins, and recent new developments on NMR-invisible SETs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.