ArticleClinical rheumatology2009
Detection of pain-related molecules in the subchondral bone of osteoarthritic knees.
Article in Clinical rheumatology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 53 citations in OpenAlex.
- Efficacy of Peripheral Cutaneous Nerve (PCN) on postoperative pain and functional outcome after total knee arthroplasty: a single-blind, randomized controlled clinical trial".BMC anesthesiology · 2025Trial
- Efficacy of combination of meloxicam and pregabalin for pain in knee osteoarthritis.Yonsei medical journal · 2013Trial
- The comparative effects of injecting intra-articular platelet-rich plasma and hypertonic dextrose prolotherapy in osteoarthritis knee - A randomized control trial.Journal of family medicine and primary care · 2025Article
- Comparative validation of the knee inflammation MRI scoring system and the MRI osteoarthritis knee score for semi-quantitative assessment of bone marrow lesions and synovitis-effusion in osteoarthritis: an international multi-reader exercise.Therapeutic advances in musculoskeletal disease · 2023Article
- Magnetic Resonance Imaging-Assessed Subchondral Cysts and Incident Knee Pain and Knee Osteoarthritis: Data From the Multicenter Osteoarthritis Study.Arthritis & rheumatology (Hoboken, N.J.) · 2022Observational
- AAAPT Diagnostic Criteria for Acute Knee Arthroplasty Pain.Pain medicine (Malden, Mass.) · 2020Article
- Association between Bone marrow lesions & synovitis and symptoms in symptomatic knee osteoarthritis.Osteoarthritis and cartilage · 2020Article
- The anti-NGF antibody muMab 911 both prevents and reverses pain behaviour and subchondral osteoclast numbers in a rat model of osteoarthritis pain.Osteoarthritis and cartilage · 2016Article
- Genome-Wide DNA Methylation Study Identifies Significant Epigenomic Changes in Osteoarthritic Subchondral Bone and Similarity to Overlying Cartilage.Arthritis & rheumatology (Hoboken, N.J.) · 2016Article
- Efficacy of Direct Injection of Etanercept into Knee Joints for Pain in Moderate and Severe Knee Osteoarthritis.Yonsei medical journal · 2015Article
- Decreased calcitonin gene-related peptide expression in the dorsal root ganglia of TNF-deficient mice in a monoiodoacetate-induced knee osteoarthritis model.International journal of clinical and experimental pathology · 2015Article
- Osteoprotegerin reduces the development of pain behaviour and joint pathology in a model of osteoarthritis.Annals of the rheumatic diseases · 2014Article
- The role of peripheral nerve fibers and their neurotransmitters in cartilage and bone physiology and pathophysiology.Arthritis research & therapy · 2014Review
- Existence of a neuropathic pain component in patients with osteoarthritis of the knee.Yonsei medical journal · 2012Article
- Pain-related sensory innervation in monoiodoacetate-induced osteoarthritis in rat knees that gradually develops neuronal injury in addition to inflammatory pain.BMC musculoskeletal disorders · 2011Article
- Objective assessments of medial osteoarthritic knee severity by MRI: new computer software to evaluate femoral condyle contours.International orthopaedics · 2010Article
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Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Knee pain is predominant among osteoarthritis (OA) patients, but the mechanism is poorly understood. We investigated subchondral bone as a source of OA knee pain using immunohistochemistry. Fifteen medial-type OA knees with minimum involvement of the lateral compartment determined by X-ray as well as magnetic resonance imaging that received total knee arthroplasty (TKA) were involved. Each pair of the medial femoral condyle (MFC) and lateral femoral condyle (LFC) was compared obtained at the time of TKA. Osteocartilaginous MFC and LFC specimens were histologically examined and stained with antibodies against cyclooxygenase 1 (Cox-1), cyclooxygenase 2 (Cox-2), substance P, tumor necrosis factor-alpha (TNF-alpha), and neuron-specific class III beta-tubulin (TUJ1), a pan-neuronal marker. Formation of cystic lesions was more frequently seen in the MFC. The lesions were composed of vascular endothelial cells, osteoclasts, and mononuclear cells and were present in similar proportions between the MFC and the LFC. Four out of 15 MFC specimens were positive for Cox-1, 15 for Cox-2, and 13 for TNF-alpha. No LFC specimens were positive for any antibodies. Substance P-positive and TUJ1-positive fibers were found in the subchondral area of the MFC, but not in the LFC. Pathological changes in the subchondral bone can be a source of knee pain, which was detectable by the positive immunoreactivity of substance P, Cox-2, TNF-alpha, and TUJ1, in the subchondral bone of affected compartments. The relatively immediate reduction in pain obtained by TKA might account for the involvement of the subchondral bone in knee pain because most of the affected subchondral plate is excised in TKA (debridement effect of TKA).
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Registered trials
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