ReviewChromosoma2010
Solving the Dnmt2 enigma.
Review in Chromosoma, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
80 citing papers in PubMed, 157 citations in OpenAlex.
- DNA Methylation Dynamics in Development and Disease: Insights from Zebrafish Models.Biomedicines · 2026Review
- Genome-Wide Identification and Expression Pattern Analysis of the DNA Methyltransferase Gene Family Revealed the DNA Methylation Response to Tapping in Rubber Tree.Plants (Basel, Switzerland) · 2025Article
- Dissecting the function of the DNMT2-homolog (DNMA) in Dictyostelium discoideum.G3 (Bethesda, Md.) · 2025Article
- Epigenetic Cross-Talk Between Sirt1 and Dnmt1 Promotes Axonal Regeneration After Spinal Cord Injury in Zebrafish.Molecular neurobiology · 2025Article
- Genome-wide identification of histone lysine methyltransferases and their implications in the epigenetic regulation of eggshell formation-related genes in a trematode parasite Clonorchis sinensis.Parasites, hosts and diseases · 2024Article
- TheNAR genomics and bioinformatics · 2023Article
- RNA methylation and cellular response to oxidative stress-promoting anticancer agents.Cell cycle (Georgetown, Tex.) · 2023Review
- Chemical Space Virtual Screening against Hard-to-Drug RNA Methyltransferases DNMT2 and NSUN6.International journal of molecular sciences · 2023Article
- Article
- DNA Methyltransferases: From Evolution to Clinical Applications.International journal of molecular sciences · 2022Review
- Article
- Malaria Parasite Stress Tolerance Is Regulated by DNMT2-Mediated tRNA Cytosine Methylation.mBio · 2021Article
- The expression and clinical significance of the tRNA aspartic acid methyltransferase 1 protein in gastric cancer.International journal of clinical oncology · 2021Article
- The lack of functionalAging · 2021Article
- Extreme Genomic CpG Deficiency in SARS-CoV-2 and Evasion of Host Antiviral Defense.Molecular biology and evolution · 2020Article
- Molecular characterization and transcription analysis of DNA methyltransferase genes in tomato (Solanum lycopersicum).Genetics and molecular biology · 2020Article
- mFrontiers in molecular biosciences · 2020Article
- Review
- c-Myc activation promotes cofilin-mediated F-actin cytoskeleton remodeling and telomere homeostasis as a response to oxidant-based DNA damage in medulloblastoma cells.Redox biology · 2019Article
- Reassessment of Viroid RNA Cytosine Methylation Status at the Single Nucleotide Level.Viruses · 2019Article
20 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dnmt2 is a member of the animal DNA methyltransferase family of enzymes. While the role of other Dnmt proteins has been extensively characterized, comparably little is known about Dnmt2. This is surprising because Dnmt2 is the most widely conserved Dnmt protein, with homologues in protists, plants, fungi, and animals. In this review, we discuss the evidence supporting the seemingly contradictory roles of Dnmt2 in both DNA and RNA methylation. New studies are uncovering the enzymatic mechanisms that mediate these activities and also provide first insights into the biological functions of Dnmt2. Lastly, we also discuss observations that suggest a possible role for Dnmt2 in human health and disease, which further emphasizes the importance of defining Dnmt2-modulated cellular pathways in future studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.