ArticleUrological research2009
Proteomic analysis of a matrix stone: a case report.
Article in Urological research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 37 citations in OpenAlex.
- Article
- Comprehensive proteomic quantification of bladder stone progression in a cystinuric mouse model using data-independent acquisitions.PloS one · 2022Article
- Article
- A Case of Pure Matrix Ureteral Stone: A rare type of urinarySultan Qaboos University medical journal · 2018Article
- Guaifenesin stone matrix proteomics: a protocol for identifying proteins critical to stone formation.Urolithiasis · 2017Article
- Label-free proteomic methodology for the analysis of human kidney stone matrix composition.Proteome science · 2016Article
- Unified theory on the pathogenesis of Randall's plaques and plugs.Urolithiasis · 2015Article
- Reactive oxygen species, inflammation and calcium oxalate nephrolithiasis.Translational andrology and urology · 2014Article
- Lack of evidence for the association of ornithine decarboxylase (+316 G>A), spermidine/spermine acetyl transferase (-1415 T>C) gene polymorphisms with calcium oxalate stone disease.Biomedical reports · 2014Article
- Matrix stone in ureter and bladder simultaneously.Japanese journal of radiology · 2012Article
- Mass spectrometry and renal calculi.Journal of medicine and lifeReview
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Matrix stones are radiolucent bodies that present as soft muco-proteinaceous material within the renal collecting system. Following wide-angle X-ray diffraction (XRD) and scanning electron microscopy (SEM), we homogenized a surgically removed matrix stone, extracted and purified protein, and analyzed samples using tandem mass spectrometry for proteomic composition. Resulting spectra were searched using ProteinPilot 2.0, and identified proteins were reported with >95% confidence. Primary XRD mineral analysis was a biological apatite, and SEM revealed fibrous, net-like laminations containing bacterial, cellular, and crystalline material. Of the 33 unique proteins identified, 90% have not been previously reported within matrix stones and over 70% may be considered inflammatory or defensive in nature. Characterization of other matrix stone proteomes, in particular from non-infectious populations, may yield insights into the pathogenesis of this rare stone as well as the mineralogical process that occurs within crystalline calculi.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.