ArticleCellular and molecular life sciences : CMLS2009
Developmental regulation of p70 S6 kinase by a G protein-coupled receptor dynamically modelized in primary cells.
Article in Cellular and molecular life sciences : CMLS, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 51 citations in OpenAlex.
- Relative Sertoli-cell FSH hyporesponsiveness as a potential contributor to sperm DNA fragmentation: a hypothesis-driven narrative review and proposal of the FERTILE framework.Frontiers in urology · 2026Article
- Testicular piRNA Analysis Identified Dysregulated piRNAs in Non-obstructive Azoospermia.Reproductive sciences (Thousand Oaks, Calif.) · 2024Article
- MAPKs signaling is obligatory for male reproductive function in a development-specific manner.Frontiers in reproductive health · 2024Review
- Follicle-stimulating hormone signaling in Sertoli cells: a licence to the early stages of spermatogenesis.Reproductive biology and endocrinology : RB&E · 2022Review
- Overview of follicle stimulating hormone and its receptors in reproduction and in stem cells and cancer stem cells.International journal of biological sciences · 2022Review
- Misfolded G Protein-Coupled Receptors and Endocrine Disease. Molecular Mechanisms and Therapeutic Prospects.International journal of molecular sciences · 2021Review
- Actions and Roles of FSH in Germinative Cells.International journal of molecular sciences · 2021Review
- Hypo-glycosylated hFSH drives ovarian follicular development more efficiently than fully-glycosylated hFSH: enhanced transcription and PI3K and MAPK signaling.Human reproduction (Oxford, England) · 2021Article
- The role of estrogen receptors in rat Sertoli cells at different stages of development.Heliyon · 2020Article
- Follicle-stimulating Hormone (FSH) Action on Spermatogenesis: A Focus on Physiological and Therapeutic Roles.Journal of clinical medicine · 2020Review
- FSH for the Treatment of Male Infertility.International journal of molecular sciences · 2020Review
- Molecular Mechanisms of Action of FSH.Frontiers in endocrinology · 2019Review
- Molecular Mechanisms and Signaling Pathways Involved in Sertoli Cell Proliferation.Frontiers in endocrinology · 2019Review
- Biased Signaling and Allosteric Modulation at the FSHR.Frontiers in endocrinology · 2019Review
- G Protein-Coupled Receptors As Regulators of Localized Translation: The Forgotten Pathway?Frontiers in endocrinology · 2018Review
- mTOR Regulates Gap Junction Alpha-1 Protein Trafficking in Sertoli Cells and Is Required for the Maintenance of Spermatogenesis in Mice.Biology of reproduction · 2016Article
- Mutations in G protein-coupled receptors that impact receptor trafficking and reproductive function.Molecular and cellular endocrinology · 2014Review
- Receptors and signaling pathways involved in proliferation and differentiation of Sertoli cells.Spermatogenesis · 2014Review
- Trafficking of the follitropin receptor.Methods in enzymology · 2013Article
- mRNA-selective translation induced by FSH in primary Sertoli cells.Molecular endocrinology (Baltimore, Md.) · 2012Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mechanisms whereby G protein-coupled receptors (GPCR) activate signalling pathways involved in mRNA translation are ill-defined, in contrast to tyrosine kinase receptors (TKR). We compared a GPCR and a TKR, both endogenously expressed, for their ability to mediate phosphorylation of 70-kDa ribosomal S6 kinase p70S6K in primary rat Sertoli cells at two developmental stages. In proliferating cells stimulated with follicle-stimulating hormone (FSH), active p70S6K was phosphorylated on T389 and T421/S424, through cAMP-dependent kinase (PKA) and phosphatidyl-inositide-3 kinase (PI3K) antagonizing actions. In FSH-stimulated differentiating cells, active p70S6K was phosphorylated solely on T389, PKA and PI3K independently enhancing its activity. At both developmental stages, insulin-induced p70S6K regulation was consistent with reported data. Therefore, TKR and GPCR trigger distinct p70S6K active conformations. p70S6K developmental regulation was formalized in a dynamic mathematical model fitting the data, which led to experimentally inaccessible predictions on p70S6K phosphorylation rate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.