ArticleJournal of vascular research2010
Modulating the functional contributions of c-Myc to the human endothelial cell cyclic strain response.
Article in Journal of vascular research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- Endothelial c-Myc knockout disrupts metabolic homeostasis and triggers the development of obesity.Frontiers in cell and developmental biology · 2024Article
- PHD2 deletion in endothelial or arterial smooth muscle cells reveals vascular cell type-specific responses in pulmonary hypertension and fibrosis.Angiogenesis · 2022Article
- BRAF Modulates Stretch-Induced Intercellular Gap Formation through Localized Actin Reorganization.International journal of molecular sciences · 2021Article
- Estimating Arterial Cyclic Strain from the Spacing of Endothelial Nuclei.Experimental mechanics · 2021Article
- Writing and erasing MYC ubiquitination and SUMOylation.Genes & diseases · 2019Review
- Endothelial Cell Biomechanical Responses are Dependent on Both Fluid Shear Stress and Tensile Strain.Cellular and molecular bioengineering · 2019Article
- Article
- Endovascular biopsy: Strategy for analyzing gene expression profiles of individual endothelial cells obtained from human vesselsBiotechnology reports (Amsterdam, Netherlands) · 2015Article
- Mechanical stretch: physiological and pathological implications for human vascular endothelial cells.Vascular cell · 2015Review
- E7080 (lenvatinib), a multi-targeted tyrosine kinase inhibitor, demonstrates antitumor activities against colorectal cancer xenografts.Neoplasia (New York, N.Y.) · 2014Article
- Angiogenic microenvironment augments impaired endothelial responses under diabetic conditions.American journal of physiology. Cell physiology · 2014Article
- Article
- Response of preosteoblasts to thermal stress conditioning and osteoinductive growth factors.Cell stress & chaperones · 2012Article
- Response of a preosteoblastic cell line to cyclic tensile stress conditioning and growth factors for bone tissue engineering.Tissue engineering. Part A · 2012Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
This study addresses whether pathological levels of cyclic strain activate the c-Myc promoter, leading to c-Myc transcription and downstream gene induction in human umbilical vein endothelial cells (HUVEC) or human aortic endothelial cells (HAEC). mRNA and protein expression of c-Myc under physiological (6-10%) and pathological cyclic strain conditions (20%) were studied. Both c-Myc mRNA and protein expression increased 2-3-fold in HUVEC cyclically strained at 20%. c-Myc protein increased 4-fold in HAEC. In HUVEC, expression of mRNA peaked at 1.5-2 h. Subsequently, the effect of modulating c-Myc on potential downstream gene targets was determined. A small molecular weight compound that binds to and stabilizes the silencer element in the c-Myc promoter attenuates cyclic strain-induced c-Myc transcription by about 50%. This compound also modulates c-Myc downstream gene targets that may be instrumental in induction of vascular disease. Cyclic strain-induced gene expression of vascular endothelial growth factor, proliferating cell nuclear antigen and heat shock protein 60 are attenuated by this compound. These results offer a possible mechanism and promising clinical treatment for vascular diseases initiated by increased cyclic strain.
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Registered trials
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