ArticlePublic health genomics2010
Considerations for designing a prototype genetic test for use in translational research.
Article in Public health genomics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03130569 (Personalized Genomic Testing for Skin Cancer - Maximizing Utility and Reach), which is not on this map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Personalized Genomic Testing for Skin Cancer - Maximizing Utility and Reach
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-Prediction of MTHFR Gene Polymorphism Mutations and Associated Risk for Colorectal Cancer.Biological research for nursing · 2016Pooled it
- Gene-Metabolite Interaction in the One Carbon Metabolism Pathway: Predictors of Colorectal Cancer in Multi-Ethnic Families.Journal of personalized medicine · 2018Article
- Pathways to precision medicine in smoking cessation treatments.Neuroscience letters · 2018Review
- Gene Environment Interactions and Predictors of Colorectal Cancer in Family-Based, Multi-Ethnic Groups.Journal of personalized medicine · 2018Article
- A new approach to assessing affect and the emotional implications of personal genomic testing for common disease risk.Public health genomics · 2015Article
- Effects of undergoing multiplex genetic susceptibility testing on parent attitudes towards testing their children.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2014Article
- On averages and peaks: how do people integrate attitudes about multiple diseases to reach a decision about multiplex genetic testing?Medical decision making : an international journal of the Society for Medical Decision Making · 2013Article
- Association between health-service use and multiplex genetic testing.Genetics in medicine : official journal of the American College of Medical Genetics · 2012Article
- Patients' understanding of and responses to multiplex genetic susceptibility test results.Genetics in medicine : official journal of the American College of Medical Genetics · 2012Article
- Preferences among diseases on a genetic susceptibility test for common health conditions: an ancillary study of the multiplex initiative.Public health genomics · 2012Article
- Modelling decisions to undergo genetic testing for susceptibility to common health conditions: an ancillary study of the Multiplex Initiative.Psychology & health · 2012Article
- Direct-to-consumer personalized genomic testing.Human molecular genetics · 2011Review
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Abstract
backgroundTranslational research is needed to explore how people will respond to personal genetic susceptibility information related to common health conditions. Maximizing the rigor of this research will require that genetic test results be returned to study participants. Currently, there is no established method that guides the selection of genetic variants to be used in research with these objectives. METHODS AND
resultsTo address this question, we designed a process to identify gene variants and health conditions to be included in a prototype genetic test for use in a larger research effort, the Multiplex Initiative. The intention of this exploration was to facilitate research that generates individual genetic test results that are returned to study participants. Inclusion criteria were developed as part of a transdisciplinary and iterative process that considered the weight of evidential support for genetic association with common health conditions, the appropriateness of use in human subjects research, and the recommendations of expert peer reviewers.
conclusionsThe selection process was designed to identify gene variants for the limited purpose of translational research and, therefore, should not be seen as producing a valid clinical test. However, this example of an applied selection process may provide guidance for researchers who are designing studies to evaluate the implications of genetic susceptibility testing through the return of personalized genetic information. As the rate of genomic discoveries increases, such research will be essential in steering the translation of this information towards the greatest public health benefit.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.