ReviewThe Journal of clinical investigation2009
Coadaptation of Helicobacter pylori and humans: ancient history, modern implications.
Review in The Journal of clinical investigation, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 278 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
278 citing papers in PubMed, 1 synthesis or guideline pooled it, 556 citations in OpenAlex.
- The association between Helicobacter pylori infection and asthma risk: an updated systematic review and meta-analysis.BMC infectious diseases · 2026Pooled it
- Effect of treatment failure on the CagA EPIYA motif inWorld journal of gastroenterology · 2017Trial
- A novel soil-derived Mycolicibacterium decreases anxiety-like defensive behavioral responses in association with decreases in biomarkers of neuroinflammation and hippocampal microglial priming in adult male rats.Brain, behavior, and immunity · 2026Article
- Review
- Animal gut microbes and microbiomes in the 21st century and beyond.Science China. Life sciences · 2026Review
- Bad bugs mean business: gastric cancer is an intended consequence ofInfection and immunity · 2026Review
- Beyond the Stomach: Exploring the Role ofExpert reviews in molecular medicine · 2026Review
- In vitro antibacterial effects and mechanism of action of six constituents of Litsea cubeba essential oil against Helicobacter pylori.World journal of microbiology & biotechnology · 2026Article
- Beyond <italic>Helicobacter pylori</italic>: Current Insights into <italic>H. pylori</italic>-Naive Gastric Cancer.Digestion · 2026Review
- Managing dangerous liaisons: lessons fromJournal of bacteriology · 2026Review
- Assembly and glycosylation ofPNAS nexus · 2026Article
- Whole genome sequence analysis ofiScience · 2025Article
- Mutations in the Ferric Uptake Regulator Gene (Microorganisms · 2025Article
- Diagnosis and treatment ofFuture microbiology · 2025Review
- Development of a prognostic nomogram and risk factor analysis for survival inTranslational cancer research · 2025Article
- Species-specific components of theInfection and immunity · 2025Article
- FlgY, PflA, and PflB form a spoke-ring network in the high-torque flagellar motor ofProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Genome-wide accumulations of non-random adaptive point mutations drive westward evolution of Helicobacter pylori.BMC microbiology · 2025Article
- Effect ofImmunotherapy · 2025Review
- Co-culture of Helicobacter pylori with oral microorganisms in human saliva.Clinical oral investigations · 2025Article
218 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Humans have been colonized by Helicobacter pylori for at least 50,000 years and probably throughout their evolution. H. pylori has adapted to humans, colonizing children and persisting throughout life. Most strains possess factors that subtly modulate the host environment, increasing the risk of peptic ulceration, gastric adenocarcinoma, and possibly other diseases. H. pylori genes encoding these and other factors rapidly evolve through mutation and recombination, changing the bacteria-host interaction. Although immune and physiologic responses to H. pylori also contribute to pathogenesis, humans have evolved in concert with the bacterium, and its recent absence throughout the life of many individuals has led to new human physiological changes. These may have contributed to recent increases in esophageal adenocarcinoma and, more speculatively, other modern diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.