ArticleJournal of applied physiology (Bethesda, Md. : 1985)2009
NOS inhibition blunts and delays the compensatory dilation in hypoperfused contracting human muscles.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 35 citations in OpenAlex.
- Inorganic nitrate supplementation enhances functional capacity and lower-limb microvascular reactivity in patients with peripheral artery disease.Nitric oxide : biology and chemistry · 2018Trial
- Dietary nitrate restores compensatory vasodilation and exercise capacity in response to a compromise in oxygen delivery in the noncompensator phenotype.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Trial
- Roles of nitric oxide and prostaglandins in the hyperemic response to a maximal metabolic stimulus: redundancy prevails.European journal of applied physiology · 2013Trial
- Absence of compensatory vasodilation with perfusion pressure challenge in exercise: evidence for and implications of the noncompensator phenotype.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Exercise vasodilation is greater in women: contributions of nitric oxide synthase and cyclooxygenase.European journal of applied physiology · 2015Article
- Regulation of increased blood flow (hyperemia) to muscles during exercise: a hierarchy of competing physiological needs.Physiological reviews · 2015Review
- A review on the mechanisms of blood-flow restriction resistance training-induced muscle hypertrophy.Sports medicine (Auckland, N.Z.) · 2015Review
- Preserved Microvascular Endothelial Function in Young, Obese Adults with Functional Loss of Nitric Oxide Signaling.Frontiers in physiology · 2015Article
- Individual susceptibility to hypoperfusion and reductions in exercise performance when perfusion pressure is reduced: evidence for vasodilator phenotypes.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Muscle blood flow, hypoxia, and hypoperfusion.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Review
- Role of nitric oxide and adenosine in the onset of vasodilation during dynamic forearm exercise.European journal of applied physiology · 2013Article
- Ischemic exercise hyperemia in the human forearm: reproducibility and roles of adenosine and nitric oxide.European journal of applied physiology · 2012Article
- Sympathetic limitation of exercise hyperemia: even hypoperfused muscle is not exempted.Frontiers in physiology · 2012Article
- α-Adrenergic Blockade Unmasks a Greater Compensatory Vasodilation in Hypoperfused Contracting Muscle.Frontiers in physiology · 2012Article
- Local control of skeletal muscle blood flow during exercise: influence of available oxygen.Journal of applied physiology (Bethesda, Md. : 1985) · 2011Review
- Visualizing calcium responses to acetylcholine convection along endothelium of arteriolar networks in Cx40BAC-GCaMP2 transgenic mice.American journal of physiology. Heart and circulatory physiology · 2011Article
- Prostaglandins do not contribute to the nitric oxide-mediated compensatory vasodilation in hypoperfused exercising muscle.American journal of physiology. Heart and circulatory physiology · 2011Article
- Contribution of adenosine to compensatory dilation in hypoperfused contracting human muscles is independent of nitric oxide.Journal of applied physiology (Bethesda, Md. : 1985) · 2011Article
- Ageing reduces the compensatory vasodilatation during hypoxic exercise: the role of nitric oxide.The Journal of physiology · 2011Article
- Nitric oxide-mediated vasodilation becomes independent of beta-adrenergic receptor activation with increased intensity of hypoxic exercise.Journal of applied physiology (Bethesda, Md. : 1985) · 2011Article
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Abstract
We previously demonstrated that skeletal muscle blood flow is restored in the exercising forearm during experimental hypoperfusion via local dilator and/or myogenic mechanisms. This study examined the role of nitric oxide (NO) in the restoration of blood flow to the active muscles during hypoperfusion. Eleven healthy subjects (10 men/1 woman; 25 +/- 1 yr of age) performed rhythmic forearm exercise (10% and 20% of maximum) while hypoperfusion was evoked by balloon inflation in the brachial artery above the elbow. Each trial included baseline, exercise, exercise with inflation, and exercise after deflation (3 min each). Forearm blood flow (FBF; ultrasound) and local (brachial artery catheter pressure, BAP) and systemic arterial pressure [mean arterial pressure (MAP); Finometer] were measured. The exercise bouts were repeated during N(G)-monomethyl-L-arginine (L-NMMA) infusion (NO synthase inhibition). Forearm vascular conductance (FVC; ml x min(-1) x 100 mmHg(-1)) was calculated from BF (ml/min) and BAP (mmHg). FBF and FVC fell acutely with balloon inflation during all trials (P < 0.01). Recovery of FBF and FVC [(inflation - nadir)/(steady-state exercise - nadir)] with L-NMMA administration was reduced during 20% exercise (FBF = 77 +/- 7% vs. 88 +/- 8%; FVC = 71 +/- 8% vs. 90 +/- 9%; P < 0.01) but not 10% exercise (FBF = 83 +/- 4% vs. 81 +/- 5%, P = 0.37; FVC = 75 +/- 10% vs. 76 +/- 7%; P = 0.44) compared with the respective control trial. The time to steady-state vasodilator response was substantially longer during the l-NMMA trials (10% = 74 +/- 4 s vs. 61 +/- 6 s; 20% = 53 +/- 4 s vs. 41 +/- 4 s; P < 0.05). Thus the magnitude and timing of the NO contribution to compensatory dilation during forearm exercise with hypoperfusion was dependent on exercise intensity. These observations suggest that NO is released by contracting muscles or that a portion of the dilation caused by ischemic metabolites is NO dependent.
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