ArticleNucleic acids research2009
A high-resolution magnetic tweezer for single-molecule measurements.
Article in Nucleic acids research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed.
- Protein force spectroscopy using magnetic tweezers: Slow and steady wins the race?Biophysical journal · 2026Review
- New feature of hMEIOB and hSPATA22 binding to ssDNA from a single-molecule perspective.Acta biochimica et biophysica Sinica · 2025Article
- Accurate drift-invariant single-molecule force calibration using the Hadamard variance.Biophysical journal · 2024Article
- Looking at Biomolecular Interactions through the Lens of Correlated Fluorescence Microscopy and Optical Tweezers.International journal of molecular sciences · 2023Review
- A Critical Review on the Sensing, Control, and Manipulation of Single Molecules on Optofluidic Devices.Micromachines · 2022Review
- Detecting Individual Proteins and Their Surface Charge Variations in Solution by the Potentiometric Nanoimpact Method.ACS sensors · 2022Article
- Parallel, linear, and subnanometric 3D tracking of microparticles with Stereo Darkfield Interferometry.Science advances · 2021Article
- Submicrometer elasticity of double-stranded DNA revealed by precision force-extension measurements with magnetic tweezers.Science advances · 2019Article
- Unfolding of a ClC chloride transporter retains memory of its evolutionary history.Nature chemical biology · 2018Article
- A Horizontal Magnetic Tweezers and Its Use for Studying Single DNA Molecules.Micromachines · 2018Article
- Review
- Integrated magnetic tweezers and single-molecule FRET for investigating the mechanical properties of nucleic acid.Methods (San Diego, Calif.) · 2016Article
- Simple horizontal magnetic tweezers for micromanipulation of single DNA molecules and DNA-protein complexes.BioTechniques · 2016Article
- Mapping the energy landscape for second-stage folding of a single membrane protein.Nature chemical biology · 2015Article
- Invincible DNA tethers: covalent DNA anchoring for enhanced temporal and force stability in magnetic tweezers experiments.Nucleic acids research · 2014Article
- Magnetic tweezers for the measurement of twist and torque.Journal of visualized experiments : JoVE · 2014Article
- Controlling magnetotactic bacteria through an integrated nanofabricated metallic island and optical microscope approach.Scientific reports · 2014Article
- Efficient illumination for microsecond tracking microscopy.PloS one · 2014Article
- Article
- Lab-on-a-chip technologies for single-molecule studies.Lab on a chip · 2013Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Magnetic tweezers (MT) are single-molecule manipulation instruments that utilize a magnetic field to apply force to a biomolecule-tethered magnetic bead while using optical bead tracking to measure the biomolecule's extension. While relatively simple to set up, prior MT implementations have lacked the resolution necessary to observe sub-nanometer biomolecular configuration changes. Here, we demonstrate a reflection-interference technique for bead tracking, and show that it has much better resolution than traditional diffraction-based systems. We enhance the resolution by fabricating optical coatings on all reflecting surfaces that optimize the intensity and contrast of the interference image, and we implement feedback control of the focal position to remove drift. To test the system, we measure the length change of a DNA hairpin as it undergoes a folding/unfolding transition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.