ArticleJournal of the American Society of Nephrology : JASN2009
p53 regulates metanephric development.
Article in Journal of the American Society of Nephrology : JASN, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 51 citations in OpenAlex.
- Aberrant centrosome biogenesis disrupts nephron and collecting duct progenitor growth and fate resulting in fibrocystic kidney disease.Development (Cambridge, England) · 2023Article
- Identification and functional interpretation of miRNAs affected by rare CNVs in CAKUT.Scientific reports · 2022Article
- Mdm4 controls ureteric bud branching via regulation of p53 activity.Mechanisms of development · 2020Article
- Metabolic requirements of the nephron.Pediatric nephrology (Berlin, Germany) · 2020Review
- Duplex kidney formation: developmental mechanisms and genetic predisposition.F1000Research · 2020Review
- Cell Death in the Kidney.International journal of molecular sciences · 2019Review
- FAT4 Fine-Tunes Kidney Development by Regulating RET Signaling.Developmental cell · 2019Article
- The role of p53 in developmental syndromes.Journal of molecular cell biology · 2019Review
- Centrosome amplification disrupts renal development and causes cystogenesis.The Journal of cell biology · 2018Article
- Conditional ablation of the prorenin receptor in nephron progenitor cells results in developmental programming of hypertension.Physiological reports · 2018Article
- Regulation of Nephron Progenitor Cell Self-Renewal by Intermediary Metabolism.Journal of the American Society of Nephrology : JASN · 2017Article
- Baseline results from the UK SIGNIFY study: a whole-body MRI screening study in TP53 mutation carriers and matched controls.Familial cancer · 2017Article
- Regulation of kidney development by the Mdm2/Mdm4-p53 axis.Journal of molecular cell biology · 2017Review
- Renal stromal miRNAs are required for normal nephrogenesis and glomerular mesangial survival.Physiological reports · 2015Article
- p53 Enables metabolic fitness and self-renewal of nephron progenitor cells.Development (Cambridge, England) · 2015Article
- Histone deacetylase 1 and 2 regulate Wnt and p53 pathways in the ureteric bud epithelium.Development (Cambridge, England) · 2015Article
- The yin and yang of kidney development and Wilms' tumors.Genes & development · 2015Review
- Genome-wide analysis of gestational gene-environment interactions in the developing kidney.Physiological genomics · 2014Article
- The MDM2-p53 pathway: multiple roles in kidney development.Pediatric nephrology (Berlin, Germany) · 2014Review
- Mdm2 is required for maintenance of the nephrogenic niche.Developmental biology · 2014Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
p53 is best known as a tumor suppressor that regulates cell-cycle, differentiation, and apoptosis pathways, but its potential role in embryonic development and organogenesis remains controversial. Here, p53(-/-) embryos bred on C57Bl6 background exhibited a spectrum of congenital abnormalities of the kidney and urinary tract, including ureteric bud (UB) ectopia, double ureters/collecting systems, delayed primary branching of the UB, and hypoplastic metanephroi. We observed ectopic UB outgrowth from the Wolffian duct (WD) in one third of p53(-/-) embryos. The prevalence of duplex was higher in embryos than in neonates, and ex vivo organ culture suggested that ectopic ureters can regress over time, leaving behind a dysplastic pole ("segmental dysgenesis"). Transgenic expression of dominant negative p53 or conditional inactivation of p53 in the UB but not in the metanephric mesenchyme lineage recapitulated the duplex phenotype. Mechanistically, p53 inactivation in the WD associated with enhanced sensitivity to glial cell line-derived neurotrophic factor (GDNF)-induced ectopic budding and potentiated phosphatidylinositol-3 kinase activation by GDNF in UB cells. Unlike several other models of UB ectopia, hypersensitivity of p53(-/-) WD to GDNF is not accompanied by reduced Sprouty-1 or anterior expansion of the GDNF domain. In summary, our data lend support for a restrictive role for p53 activity in UB outgrowth from the WD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.