SynthesisHuman molecular genetics2009
Genetic variation in GPR133 is associated with height: genome wide association study in the self-contained population of Sorbs.
Synthesis in Human molecular genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed, 3 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- Genome wide meta-analysis highlights the role of genetic variation in RARRES2 in the regulation of circulating serum chemerin.PLoS genetics · 2014Pooled it
- Genome-wide association study in Han Chinese identifies three novel loci for human height.Human genetics · 2013Pooled it
- Effects of SLC10A2 variant rs9514089 on gallstone risk and serum cholesterol levels- meta-analysis of three independent cohorts.BMC medical genetics · 2011Pooled it
- The therapeutic potential of orphan adhesion G-protein-coupled receptors.Nature reviews. Drug discovery · 2026Review
- Exogenous activation of the adhesion GPCR ADGRD1/GPR133 protects against bone loss by negatively regulating osteoclastogenesis.Science advances · 2025Article
- The mechanosensitive adhesion G protein-coupled receptor 133 (GPR133/ADGRD1) enhances bone formation.Signal transduction and targeted therapy · 2025Article
- Single-marker and haplotype-based genome-wide association studies for the number of teats in two heavy pig breeds.Animal genetics · 2021Article
- The Effect of FGF21 and Its Genetic Variants on Food and Drug Cravings, Adipokines and Metabolic Traits.Biomedicines · 2021Article
- Control of oviductal fluid flow by the G-protein coupled receptor Adgrd1 is essential for murine embryo transit.Nature communications · 2021Article
- m6A Regulators in Human Adipose Tissue - Depot-Specificity and Correlation With Obesity.Frontiers in endocrinology · 2021Article
- Genetically programmed changes in transcription of the novel progranulin regulator.Journal of molecular medicine (Berlin, Germany) · 2020Article
- The expanding functional roles and signaling mechanisms of adhesion G protein-coupled receptors.Annals of the New York Academy of Sciences · 2019Article
- Article
- Metabolic effects of genetic variation in the human REPIN1 gene.International journal of obesity (2005) · 2019Article
- The role of GPCRs in bone diseases and dysfunctions.Bone research · 2019Review
- Widely Used Commercial ELISA Does Not Detect Precursor of Haptoglobin2, but Recognizes Properdin as a Potential Second Member of the Zonulin Family.Frontiers in endocrinology · 2018Article
- GPR133 (ADGRD1), an adhesion G-protein-coupled receptor, is necessary for glioblastoma growth.Oncogenesis · 2016Article
- Functional relevance of naturally occurring mutations in adhesion G protein-coupled receptor ADGRD1 (GPR133).BMC genomics · 2016Article
- Integration of Genome-Wide SNP Data and Gene-Expression Profiles Reveals Six Novel Loci and Regulatory Mechanisms for Amino Acids and Acylcarnitines in Whole Blood.PLoS genetics · 2015Article
- Genetic variants in AKR1B10 associate with human eating behavior.BMC genetics · 2015Article
Corrections and comments
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Authors and funding
20 authors at 6 institutions in 4 countries.
Funding
Abstract
Recently, associations of several common genetic variants with height have been reported in different populations. We attempted to identify further variants associated with adult height in a self-contained population (the Sorbs in Eastern Germany) as discovery set. We performed a genome wide association study (GWAS) (approximately 390,000 genetic polymorphisms, Affymetrix gene arrays) on adult height in 929 Sorbian individuals. Subsequently, the best SNPs (P < 0.001) were taken forward to a meta-analysis together with two independent cohorts [Diabetes Genetics Initiative, British 1958 Birth Cohort, (58BC, publicly available)]. Furthermore, we genotyped our best signal for replication in two additional German cohorts (Leipzig, n = 1044 and Berlin, n = 1728). In the primary Sorbian GWAS, we identified 5 loci with a P-value < 10(-5) and 455 SNPs with P-value < 0.001. In the meta-analysis on those 455 SNPs, only two variants in GPR133 (rs1569019 and rs1976930; in LD with each other) retained a P-value at or below 10(-6) and were associated with height in the three cohorts individually. Upon replication, the SNP rs1569019 showed significant effects on height in the Leipzig cohort (P = 0.004, beta = 1.166) and in 577 men of the Berlin cohort (P = 0.049, beta = 1.127) though not in women. The combined analysis of all five cohorts (n = 6,687) resulted in a P-value of 4.7 x 10(-8) (beta = 0.949). In conclusion, our GWAS suggests novel loci influencing height. In view of the robust replication in five different cohorts, we propose GPR133 to be a novel gene associated with adult height.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.