Trial reportThe journal of pain2009
Comparative cognitive and subjective side effects of immediate-release oxycodone in healthy middle-aged and older adults.
Trial report in The journal of pain, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02945293 (Cognitive, Behavioral and Aging Effects of Pain Medication in Alcohol Users), which is not on this map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Cognitive, Behavioral and Aging Effects of Pain Medication in Alcohol Users
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- A systematic review of amnestic and non-amnestic mild cognitive impairment induced by anticholinergic, antihistamine, GABAergic and opioid drugs.Drugs & aging · 2012Pooled it
- Subjective, psychomotor, and physiological effects of oxycodone alone and in combination with ethanol in healthy volunteers.Psychopharmacology · 2011Trial
- Oxycodone lengthens reproductions of suprasecond time intervals in human research volunteers.Behavioural pharmacology · 2011Trial
- Trial
- Trial
- A Qualitative Study of the Effects of Opioids on Chronic Pain, Function, and Cognition in Community-Dwelling Older Adults.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2025Article
- Escalated oxycodone self-administration is associated with expression of voltage gated and calcium activated potassium channels in the mesocorticolimbic system in rats.Frontiers in pharmacology · 2025Article
- The effects of chronic neuropathic pain states on the discriminative stimulus effect of fentanyl and other MOR agonists.bioRxiv : the preprint server for biology · 2024Article
- History of Psychoactive Medication a Risk Factor for Neurocognitive Decline After Cardiac Surgery.The Journal of surgical research · 2024Article
- Pain, Opioid Analgesics, and Cognition: A Conceptual Framework in Older Adults.Pain medicine (Malden, Mass.) · 2023Article
- Prescription opioids and longitudinal changes in cognitive function in older adults: A population-based observational study.Journal of the American Geriatrics Society · 2022Observational
- Incident Functional Limitations Among Community-Dwelling Adults Using Opioids: A Retrospective Cohort Study Using a Propensity Analysis with the Health and Retirement Study.Drugs & aging · 2022Article
- Comparison of the Impacts of Under-Treated Pain and Opioid Pain Medication on Cognitive Impairment.Cureus · 2022Review
- Elevated customary alcohol consumption attenuates opioid effects.Pharmacology, biochemistry, and behavior · 2021Article
- Opioid Use and Driving Performance.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2021Review
- Neurocognitive functioning in patients with conversion disorder/functional neurological disorder.Journal of neuropsychology · 2021Article
- Cognition and Pain: A Review.Frontiers in psychology · 2021Review
- Article
- Targeting the Orexin System for Prescription Opioid Use Disorder.Brain sciences · 2020Review
- Targeting the orexin system for prescription opioid use disorder: Orexin-1 receptor blockade prevents oxycodone taking and seeking in rats.Neuropharmacology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
unlabelledThis study measured the objective and subjective neurocognitive effects of a single 10-mg dose of immediate-release oxycodone in healthy, older (> 65 years), and middle-aged (35 to 55 years) adults who were not suffering from chronic or significant daily pain. Seventy-one participants completed 2 separate study days and were blind to medication condition (placebo, 10-mg oxycodone). Plasma oxycodone concentration peaked between 60 and 90 minutes postdose (P < .01) and pupil size, an indication of physiological effects of the medication, peaked at approximately 90 to 120 minutes postdose (P < .01). Significant declines in simple and sustained attention, working memory, and verbal memory were observed at 1 hour postdose compared to baseline for both age groups with a trend toward return to baseline by 5 hours postdose. For almost all cognitive measures, there were no medication by age-interaction effects, which indicates that the 2 age groups exhibited similar responses to the medication challenge. This study suggests that for healthy older adults who are not suffering from chronic pain, neurocognitive and pharmacodynamic changes in response to a 10-mg dose of immediate-release oxycodone are similar to those observed for middle-aged adults. PERSPECTIVE: Study findings indicate that the metabolism, neurocognitive effects, and physical side effects of oral oxycodone are similar for healthy middle-aged and older adults. Therefore, clinicians should not avoid prescribing oral opioids to older adults based on the belief that older adults are at higher risk for side effects than younger adults.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.