Evidence map›Paper›PMID 19729090›Full record

ReviewAdvances in applied microbiology2009

Chapter 2: Biogenesis of the cell wall and other glycoconjugates of Mycobacterium tuberculosis.

Devinder Kaur, Marcelo E Guerin, Henrieta Skovierová, Patrick J Brennan, Mary Jackson

Abstract readReview
In one paragraph

Review in Advances in applied microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers.

0numbers the graph read from it
0cells of the map it votes in
99citing papers in PubMed
71.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

99 citing papers in PubMed, 212 citations in OpenAlex.

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39 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Devinder KaurDepartment of Microbiology, Immunology and Pathology, Mycobacteria Research Laboratories, Colorado State University, Fort Collins, CO 80523-1682, USA.
Marcelo E Guerin
Henrieta Skovierová
Patrick J Brennan
Mary Jackson
Colorado State University · US

Funding

Biogenesis of Lipoarabinomannan in MycobacteriaR01AI064798 · NIAID · COLORADO STATE UNIVERSITY-FORT COLLINS · PI JACKSON, MARY · 2005 to 2019
$5.4M
SURFACE ANTIGENS OF M LEPRAE AND OTHER MYCOBACTERIAR37AI018357 · NIAID · COLORADO STATE UNIVERSITY-FORT COLLINS · PI BRENNAN, PATRICK JOSEPH · 1988 to 2007
$2.7M
MYOCOBACTERIAL CELL WALL AND DRUG DISCOVERYR01AI018357 · NIAID · COLORADO STATE UNIVERSITY-FORT COLLINS · PI BRENNAN, PATRICK JOSEPH · 1998 to 2000
$421k
SPECIFIC ANTIGENS OF ATYPICAL MYCOBACTERIAR22AI018357 · NIAID · COLORADO STATE UNIVERSITY-FORT COLLINS · PI BRENNAN, PATRICK JOSEPH · 1985 to 1987
–
NIAID NIH HHS AI18357NIAID NIH HHS AI64798NIAID NIH HHS R01 AI018357NIAID NIH HHS R01 AI064798NIAID NIH HHS R37 AI018357
6 · The paper itself

Abstract

The re-emergence of tuberculosis in its present-day manifestations - single, multiple and extensive drug-resistant forms and as HIV-TB coinfections - has resulted in renewed research on fundamental questions such as the nature of the organism itself, Mycobacterium tuberculosis, the molecular basis of its pathogenesis, definition of the immunological response in animal models and humans, and development of new intervention strategies such as vaccines and drugs. Foremost among these developments has been the precise chemical definition of the complex and distinctive cell wall of M. tuberculosis, elucidation of the relevant pathways and underlying genetics responsible for the synthesis of the hallmark moieties of the tubercle bacillus such as the mycolic acid-arabinogalactan-peptidoglycan complex, the phthiocerol- and trehalose-containing effector lipids, the phosphatidylinositol-containing mannosides, lipomannosides and lipoarabinomannosides, major immunomodulators, and others. In this review, the laboratory personnel who have been the focal point of some to these developments review recent progress towards a comprehensive understanding of the basic physiology and functions of the cell wall of M. tuberculosis.

Indexed as

AnimalsAnti-Bacterial AgentsAntitubercular AgentsBacterial CapsulesBacterial ProteinsCell WallDrug DesignGalactansGlycoconjugatesHumansMycobacterium tuberculosisMycolic AcidsPeptidoglycanPolysaccharides, BacterialTuberculosisAnti-Bacterial AgentsAntitubercular AgentsarabinogalactanBacterial ProteinsGalactansGlycoconjugatesMycolic AcidsPeptidoglycanPolysaccharides, Bacterial

Identifiers

PMID19729090
PMCPMC3066434
OpenAlexW1595344516

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.