ReviewBrain research bulletin2010
The molecular pathology of schizophrenia--focus on histone and DNA modifications.
Review in Brain research bulletin, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- The NLRP3 inflammasome: pathophysiology and therapeutic implications for schizophrenia and neuropsychiatric disorders.Molecular psychiatry · 2026Review
- Exploration of schizophrenia-associated gene modules using graph theory, co-expression networks, and dimensionality reduction.PloS one · 2026Article
- Methylome-wide Association Study of Patients with Recent-onset Psychosis.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2022Article
- Genomewide alteration of histone H3K4 methylation underlies genetic vulnerability to psychopathology.Journal of genetics · 2021Article
- Regulation of Social Stress and Neural Degeneration by Activity-Regulated Genes and Epigenetic Mechanisms in Dopaminergic Neurons.Molecular neurobiology · 2020Review
- GABAergic inhibitory neurons as therapeutic targets for cognitive impairment in schizophrenia.Acta pharmacologica Sinica · 2018Review
- Maternal Diabetes and Fetal Programming Toward Neurological Diseases: Beyond Neural Tube Defects.Frontiers in endocrinology · 2018Review
- Effects of Antipsychotic Drugs on the Epigenetic Modification of Brain-Derived Neurotrophic Factor Gene Expression in the Hippocampi of Chronic Restraint Stress Rats.Neural plasticity · 2018Article
- Epigenetic mechanisms underlying NMDA receptor hypofunction in the prefrontal cortex of juvenile animals in the MAM model for schizophrenia.Journal of neurochemistry · 2017Article
- Transcriptional and epigenetic mechanisms of early cortical development: An examination of how Pax6 coordinates cortical development.The Journal of comparative neurology · 2016Review
- DNA Methylation of BDNF Gene in Schizophrenia.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
- Epigenetic mechanisms in schizophrenia.Progress in biophysics and molecular biology · 2015Review
- Methylation patterns in whole blood correlate with symptoms in schizophrenia patients.Schizophrenia bulletin · 2014Article
- Animal models of brain maldevelopment induced by cycad plant genotoxins.Birth defects research. Part C, Embryo today : reviews · 2013Review
- BioTile, a Perl based tool for the identification of differentially enriched regions in tiling microarray data.BMC bioinformatics · 2013Article
- H3K4 tri-methylation in synapsin genes leads to different expression patterns in bipolar disorder and major depression.The international journal of neuropsychopharmacology · 2013Article
- A cell epigenotype specific model for the correction of brain cellular heterogeneity bias and its application to age, brain region and major depression.Epigenetics · 2013Article
- Disease- and age-related changes in histone acetylation at gene promoters in psychiatric disorders.Translational psychiatry · 2011Article
- Proteomic investigation of epigenetics in neuropsychiatric disorders: a missing link between genetics and behavior?Journal of proteome research · 2011Review
- The HDAC Inhibitor Phenylbutyrate Reverses Effects of Neonatal Ventral Hippocampal Lesion in Rats.Frontiers in psychiatry · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Dysfunction of cerebral cortex and other brain regions in schizophrenia is often accompanied by dysregulated expression of numerous genes. However, the underlying genetic risk architecture remains unclear for a large majority of cases. Therefore, the study of epigenetic regulators of gene expression, including covalent modifications of DNA and nucleosome core histones, offers an attractive alternative to further explore the molecular pathology of schizophrenia beyond the level of RNA quantification. Several studies reported alterations in DNA cytosine methylation and histone methylation at specific genes and promoters in postmortem brain of subjects with schizophrenia, often in conjunction with changes in levels of the corresponding RNAs. While evidence for such "epigenetic dysregulation" is increasing, many of the reported alterations await independent replication. Interestingly, studies across the lifespan indicate that DNA and histone methylation markings are developmentally regulated in human cerebral cortex, suggesting that at least some of the epigenetic changes in the brain of adult subjects with schizophrenia reflect disordered neurodevelopment.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.