ArticleGenome biology2009
Genome-wide prioritization of disease genes and identification of disease-disease associations from an integrated human functional linkage network.
Article in Genome biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 119 papers.
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Who cites it
119 citing papers in PubMed.
- Reconciling multiple connectivity-based systems biology methods for drug repurposing.Briefings in bioinformatics · 2025Review
- Where do obesity and male infertility collide?BMC medical genomics · 2024Article
- New treatment alternatives for primary and metastatic colorectal cancer by an integrated transcriptome and network analyses.Scientific reports · 2024Article
- Article
- Detecting biased validation of predictive models in the positive-unlabeled setting: disease gene prioritization case study.Bioinformatics advances · 2023Article
- Functional regulations between genetic alteration-driven genes and drug target genes acting as prognostic biomarkers in breast cancer.Scientific reports · 2022Article
- Discovering potential interactions between rare diseases and COVID-19 by combining mechanistic models of viral infection with statistical modeling.Human molecular genetics · 2022Article
- Prioritizing Suggestive Candidate Genes in Migraine: An Opinion.Frontiers in neurology · 2022Article
- Expression of long noncoding RNAFrontiers in endocrinology · 2022Article
- In silico identification of novel biomarkers for key players in transition from normal colon tissue to adenomatous polyps.PloS one · 2022Article
- Disease gene prediction with privileged information and heteroscedastic dropout.Bioinformatics (Oxford, England) · 2021Article
- Preclinical validation of therapeutic targets predicted by tensor factorization on heterogeneous graphs.Scientific reports · 2020Article
- CERENKOV3: Clustering and molecular network-derived features improve computational prediction of functional noncoding SNPs.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2020Article
- Machine Learning for Integrating Data in Biology and Medicine: Principles, Practice, and Opportunities.An international journal on information fusion · 2019Article
- Applications of molecular networks in biomedicine.Biology methods & protocols · 2019Review
- The variome concept: focus on CNVariome.Molecular cytogenetics · 2019Article
- Comparative analysis of cellular expression pattern of schizophrenia risk genes in human versus mouse cortex.Cell & bioscience · 2019Article
- Immune-centric network of cytokines and cells in disease context identified by computational mining of PubMed.Nature biotechnology · 2018Article
- Identifying noncoding risk variants using disease-relevant gene regulatory networks.Nature communications · 2018Article
- Learning bundled care opportunities from electronic medical records.Journal of biomedical informatics · 2018Article
59 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors.
Funding
Abstract
We integrate 16 genomic features to construct an evidence-weighted functional-linkage network comprising 21,657 human genes. The functional-linkage network is used to prioritize candidate genes for 110 diseases, and to reliably disclose hidden associations between disease pairs having dissimilar phenotypes, such as hypercholesterolemia and Alzheimer's disease. Many of these disease-disease associations are supported by epidemiology, but with no previous genetic basis. Such associations can drive novel hypotheses on molecular mechanisms of diseases and therapies.
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