Evidence map›Paper›PMID 19728860›Full record

ArticleClinical science (London, England : 1979)2010

Obesity is the major contributor to vascular dysfunction and inflammation in high-fat diet hypertensive rats.

Ahmed A Elmarakby, John D Imig

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical science (London, England : 1979), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 87 citations in OpenAlex.

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  17. Loss of hepatic PPARα promotes inflammation and serum hyperlipidemia in diet-induced obesity.American journal of physiology. Regulatory, integrative and comparative physiology · 2019
    Article
  18. HO-1 overexpression and underexpression: Clinical implications.Archives of biochemistry and biophysics · 2019
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Ahmed A ElmarakbyDepartment of Oral Biology/Pharmacology, Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912, U.S.A.. aelmarakby@mcg.edu
John D Imig
Augusta University · USMedical College of Wisconsin · US

Funding

OXYGENASE METABOLITES AND RENAL VASCULAR ACTIVITYR01HL059699 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI IMIG, JOHN D · 1999 to 2011
$3.0M
OXYGENASE METABOLITES AND RENAL VASCULAR ACTIVITYR29HL059699 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI IMIG, JOHN D · 1998 to 1998
–
NHLBI NIH HHS HL59699NHLBI NIH HHS R01 HL059699
6 · The paper itself

Abstract

Obesity and hypertension are the two major risk factors that contribute to the progression of end-stage renal disease. To examine whether hypertension further exacerbates oxidative stress and vascular dysfunction and inflammation in obese rats, four groups of male Sprague-Dawley rats were fed either a normal (7% fat) or high-fat (36% fat) diet for 6 weeks and osmotic pumps were implanted to deliver ANG (angiotensin II) or vehicle for an additional 4 weeks.Treatment with the high-fat diet did not alter ANG-induced hypertension compared with the normal diet (174 +/- 6 compared with 170 +/- 5 mmHg respectively). Treatment with the high-fat diet increased body weight gain and plasma leptin levels and induced insulin resistance in normotensive and ANG-induced hypertensive rats. Plasma TBARS (thiobarbituric acid-reacting substances), a measure of oxidative stress, were elevated in high-fat diet-fed rats compared with controls (11.2 +/-1 compared with 8.4 +/- nmol/ml respectively) and was increased further in ANG-induced hypertensive rats fed a high-fat diet (18.8 +/-2.2 nmol/ml). Urinary nitrite excretion was also decreased in rats fed a high-fat diet without or with ANG infusion compared with controls. Afferent arteriolar relaxation to acetylcholine was impaired in rats fed the high-fat diet without or with ANG infusion. Renal cortical TNF-alpha(tumour necrosis factor-alpha), COX-2(cyclo-oxygenase-2) and phospho-IKK (inhibitor of nuclear factor k B kinase) expression increased in high-fat diet-fed rats compared with normal diet-fed rats. The increases in phospho-IKK and COX-2 expression were elevated further in ANG-induced hypertensive rats fed the high-fat diet.These results suggest that ANG-induced hypertension exacerbates oxidative stress and renal inflammation without further impairment in vascular dysfunction in high-fat diet-induced obesity.

Indexed as

Oxidative StressAcetylcholineAngiotensin IIAnimalsBlood GlucoseBlood PressureCyclooxygenase 2Dietary FatsEndothelium, VascularHypertensionI-kappa B KinaseInsulin ResistanceKidneyLipidsMaleNephritisAcetylcholineAngiotensin IIBlood GlucoseCyclooxygenase 2Dietary FatsI-kappa B KinaseLipidsNF-kappa BNitritesThiobarbituric Acid Reactive SubstancesTumor Necrosis Factor-alphaVasoconstrictor Agents

Identifiers

PMID19728860
PMCPMC2842481
OpenAlexW1987157579

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.