Evidence map›Paper›PMID 19728140›Full record

ArticleJournal of inherited metabolic disease2009

Total oxidant-scavenging capacities of plasma from glycogen storage disease type Ia patients as measured by cyclic voltammetry, FRAP and luminescence techniques.

E Koren, J Lipkin, A Klar, E Hershkovitz, I Ginsburg, R Kohen

Abstract readEvaluation Study
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In one paragraph

Article in Journal of inherited metabolic disease, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

E KorenDepartment of Pharmaceutics, School of Pharmacy, Richard and Jean Zarbin Chair in Medical Studies, Hebrew University, Hadassah Faculty of Medicine, Jerusalem, 91120, Israel.
J LipkinDepartment of Pediatrics, Bikur Cholim General Hospital, Jerusalem, Israel.
A KlarDepartment of Pediatrics, Bikur Cholim General Hospital, Jerusalem, Israel.
E HershkovitzPediatric Endocrinology & Metabolic Unit, Soroka Medical University Center, Beer Sheva, Israel.
I GinsburgFaculty of Dental Medicine, Institute for Dental Sciences, Hebrew University, Hadassah Medical Center, Jerusalem, Israel.
R KohenDepartment of Pharmaceutics, School of Pharmacy, Richard and Jean Zarbin Chair in Medical Studies, Hebrew University, Hadassah Faculty of Medicine, Jerusalem, 91120, Israel. ronk@ekmd.huji.ac.il.
Bikur Cholim Hospital · ILHebrew University of Jerusalem · ILHadassah Medical Center · ILSoroka Medical Center · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It has been suggested that the very low incidence of atherosclerosis in glycogen storage disease type Ia (GSD Ia) subjects might be attributed to elevated levels of uric acid, one of the potent low molecular- weight antioxidants found in plasma. The present communication describes a use of two analytical methods-cyclic voltammetry and ferric reducing ability of plasma-and also two chemiluminescence methods to evaluate the total oxidant-scavenging capacities (TOSC) of plasma from GSD Ia patients. Our results verified the elevation of TOSC in GSD Ia patients and we propose the inclusion of luminescence and cyclic voltammetry assays as reliable methods for estimating TOSC in a variety of clinical disorders. Our findings with the cyclic voltammetry method add support to the assumption that the elevated uric acid levels might be the main contributor to plasma antioxidant capacity and possible protection against atherosclerosis.

Indexed as

Fluorescence Recovery After PhotobleachingAdolescentAdultCase-Control StudiesChildChild, PreschoolElectric ConductivityElectrochemistryFree Radical ScavengersGlycogen Storage Disease Type IHumansLuminescent MeasurementsLuminolOxidantsOxidation-ReductionReproducibility of ResultsFree Radical ScavengersLuminolOxidants

Identifiers

PMID19728140
OpenAlexW2072812972

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.