ArticleGenetica2010
Parasite mediated homogenizing selection at the MHC in guppies.
Article in Genetica, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Macroimmunology: The drivers and consequences of spatial patterns in wildlife immune defence.The Journal of animal ecology · 2020Pooled it
- Effects of Genetic Diversity on Health Status and Parasitological Traits in a Wild Fish Population Inhabiting a Coastal Lagoon.Animals : an open access journal from MDPI · 2025Article
- Balancing selection shapes population differentiation of major histocompatibility complex genes in wild golden snub-nosed monkeys.Current zoology · 2024Article
- Shoaling guppies evade predation but have deadlier parasites.Nature ecology & evolution · 2022Article
- Selection and demography drive range-wide patterns of MHC-DRB variation in mule deer.BMC ecology and evolution · 2022Article
- Functional immunogenetic variation, rather than local adaptation, predicts ectoparasite infection intensity in a model fish species.Molecular ecology · 2021Article
- Balancing selection versus allele and supertype turnover in MHC class II genes in guppies.Heredity · 2021Article
- Depletion of MHC supertype during domestication can compromise immunocompetence.Molecular ecology · 2021Article
- Parasite diversity and ecology in a model species, the guppy (Royal Society open science · 2020Article
- Polymorphism of MHC class IIB in an acheilognathid species, Rhodeus sinensis shaped by historical selection and recombination.BMC genetics · 2019Article
- Evidence for contemporary and historical gene flow between guppy populations in different watersheds, with a test for associations with adaptive traits.Ecology and evolution · 2019Article
- Microparasite dispersal in metapopulations: a boon or bane to the host population?Proceedings. Biological sciences · 2018Article
- Immunogenetic novelty confers a selective advantage in host-pathogen coevolution.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Evolutionary genetics of immunological supertypes reveals two faces of the Red Queen.Nature communications · 2017Article
- Isolation over 35 years in a heated biotest basin causes selection on MHC class IIß genes in the European perch (Perca fluviatilis L.).Ecology and evolution · 2015Article
- Experimental evolution of parasite resistance in wild guppies: natural and multifarious selection.Proceedings. Biological sciences · 2014Article
- Parasite-mediated selection of major histocompatibility complex variability in wild brandt's voles (Lasiopodomys brandtii) from Inner Mongolia, China.BMC evolutionary biology · 2013Article
- Article
- Are host-parasite interactions influenced by adaptation to predators? A test with guppies and Gyrodactylus in experimental stream channels.Oecologia · 2012Article
- Divergent selection on locally adapted major histocompatibility complex immune genes experimentally proven in the field.Ecology letters · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding the selective forces influencing genetic diversity is a fundamental goal of evolutionary ecology. The genes of the major histocompatibility complex (MHC) play a key role in the adaptive immune response of vertebrates and thus provide an excellent opportunity to examine the agents of selection on a functionally important gene. Here we examine the genetic architecture of the MHC class IIB genes in 10 wild populations of guppies (Poecilia reticulata) in Northern Trinidad. We have previously shown that these populations are significantly less diverged at the class IIB locus than expected based on neutral (microsatellite) loci. We now survey infection by Gyrodactylus turnbulli and G. bullatarudis, common parasitic worms that infect guppies, as a potential agent of homogenizing selection. We used a genetic algorithm to partition both additive and non-additive genetic effects of the five most common MHC allele types as well as a rare allele category. Although we found no evidence for non-additive effects, across the populations we found that one allele type (the a-type) had a significant negative additive effect on parasite load. Thus, individuals who had more copies of the a-type allele were infected with fewer gyrodactylus than individuals with fewer copies of the allele. These results not only link parasite infection with MHC genotype, they provide a mechanism of homogenizing selection across these otherwise disparate populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.