ArticleMolecular and cellular biochemistry2010
Association between transforming growth factor beta1 polymorphisms and left ventricle hypertrophy in essential hypertensive subjects.
Article in Molecular and cellular biochemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Polymorphisms and plasma level of transforming growth factor-Beta 1 and risk for preeclampsia: a systematic review.PloS one · 2014Pooled it
- TGF-Disease markers · 2018Article
- The profile of selected single nucleotide polymorphisms in patients with hypertension and heart failure with preserved and mid-range ejection fraction.Scientific reports · 2017Article
- The association between BMP4 gene polymorphism and its serum level with the incidence of LVH in hypertensive patients.Journal of translational medicine · 2015Article
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- Tumor PHD2 expression is correlated with clinical features and prognosis of patients with HCC receiving liver resection.Medicine · 2014Article
- Serum osteopontin, but not OPN gene polymorphism, is associated with LVH in essential hypertensive patients.Journal of molecular medicine (Berlin, Germany) · 2014Article
- Article
- BMP-4 genetic variants and protein expression are associated with platinum-based chemotherapy response and prognosis in NSCLC.BioMed research international · 2014Article
- Association between transforming growth factor beta1 polymorphisms and atrial fibrillation in essential hypertensive subjects.Journal of biomedical science · 2010Article
- The Relationship between the Transforming Growth Factor β1 T29C Gene Polymorphism and Left Ventricular Geometry and Function in Hypertensive Subjects.International journal of hypertension · 2010Article
- Adducin 1 (alpha) Gly460Trp variant is associated with left ventricular geometry in Caucasians and African Americans: The HyperGEN Study.International journal of molecular epidemiology and genetics · 2010Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Left ventricular hypertrophy (LVH) increases the risk of cardiovascular morbid events in hypertension. TGF-beta1 is involved in pathologic states such as cardiac hypertrophy and cardiac fibrosis; we thus postulate that the TGF-beta1 polymorphism is related to LVH in hypertensives. Six hundred and eighty essential hypertensive patients were recruited. Biochemical variables and clinical data were obtained and the determination of LVH was performed by echocardiography. According to the presence of LVH, all subjects were divided into the LVH+ and LVH- group. DNA was obtained, and two coding region polymorphisms of the TGF-beta1 gene (+869 Leu-->Proat codon 10 and +915 ARG-->Pro at codon 25) were analyzed by the polymerase chain reaction. The product was cleaved with the restriction endonucleases. For the polymorphisms of the +869 Leu-->Pro at codon 10, there was no marked difference in the distributions of genotypes and the allele frequencies between the LVH+ and LVH- subjects. For +915 Arg-->Pro at codon 25, a significant difference in the distributions of genotypes of TGF-beta1 was observed. The left ventricular mass index (LVMI) in Arg-Pro genotype carriers was significantly higher than those in the Arg-Arg and Pro-Pro carriers. Multivariate analysis showed that the Arg-Pro genotype was an independent risk factor for LVH (OR 3.23, 95% CI [1.48-5.63, P = 0.002]). The codon 10 genotypes did not show a significant association to LVH. Our data revealed a genetic association of TGF-beta1+915 Arg-->Pro at codon 25 polymorphism with LVH in a Chinese hypertensive population.
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