ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2009
Circulating cytokeratin 18 fragment m65-a potential marker of malignancy in colorectal cancer patients.
Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Presence of bone marrow micro-metastases in stage I-III colon cancer patients is associated with worse disease-free and overall survival.Cancer medicine · 2017Trial
- Monitoring apoptosis and Bcl-2 on circulating tumor cells in patients with metastatic breast cancer.Molecular oncology · 2013Trial
- Hsa-miR-186-3p suppresses colon cancer progression by inhibiting KRT18/MAPK signaling pathway.Cell cycle (Georgetown, Tex.) · 2022Article
- Multifaceted role of keratins in epithelial cell differentiation and transformation.Journal of biosciences · 2019Review
- The roles of M30 and M65 in the assessment of treatment response and prognosis in patients with non-small cell lung cancer, who receive neoadjuvant treatment.Contemporary oncology (Poznan, Poland) · 2019Article
- M30/M65 ratio predicts the outcome of paclitaxel chemotherapy for NSCLC.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2017Article
- Phenotypic characterization of circulating tumor cells in the peripheral blood of patients with small cell lung cancer.PloS one · 2017Article
- Can circulating M30 and M65 levels be beneficial markers in the diagnosis and management of patients with complete hydatidiform mole?Wiener klinische Wochenschrift · 2016Article
- Circulating Levels of M30 and M65 Molecules in Transitional Cell Carcinoma of the Bladder and Their Relation to Tumor Progression.Iranian journal of cancer prevention · 2016Article
- Significance of Serum Cytokeratin-18 in Prediction of Hepatocellular Carcinoma in Chronic Hepatitis C Infected Egyptian Patients.Open access Macedonian journal of medical sciences · 2015Article
- Cytokeratins in gastroenterology. Systematic review.Przeglad gastroenterologiczny · 2015Review
- Clinical significance of serum M30 and M65 levels in metastatic pancreatic adenocarcinoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Article
- Multi-level evidence that circulating CK18 is a biomarker of tumour burden in colorectal cancer.British journal of cancer · 2012Article
- Keratins in colorectal epithelial function and disease.International journal of experimental pathology · 2012Review
- Serum M30 and M65 values in patients with advanced stage non-small-cell lung cancer compared with controls.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2012Article
- Biology and significance of circulating and disseminated tumour cells in colorectal cancer.Langenbeck's archives of surgery · 2012Review
- Novel serum proteomic signatures in a non-human primate model of retinal injury.Molecular vision · 2011Article
- Circulating cytokeratin 18 fragments and activation of dormant tumor cells in bone marrow of cancer patients.Experimental and therapeutic medicine · 2010Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Soluble cytokeratin 18 fragments (M30, M65) are released from human cancer cells during cell death and hold potential as biomarkers in colorectal cancer characterized by frequent metastatic spread. A total of 62 colorectal cancer and 27 control patients were included in the study. M65 (necrosis and apoptosis) and M30 (apoptosis) were quantified preoperatively (n = 62) and postoperatively (n = 31) using specific enzyme-linked immunosorbent assays. Presence of disseminated tumor cells (DTC) in the bone marrow was assessed by staining of A45-B/B3-positive cells in aspirates. M65 was significantly elevated in patients with International Union against Cancer stage I and IIA tumors compared to controls. A subgroup (19/31) exhibited a significant (p < 0.05) decrease of M65 after tumor surgery (503.9 +/- 230.7 to 342.6 + 94.8 U/l; -32.0 +/- 16.5%), in contrast to 12 patients who revealed higher M65 levels postoperatively (386.5 +/- 128.5 to 519.1 +/- 151 U/l; +37.4 +/- 32.3%). DTC in bone marrow were found in 10% (2/19) of patients with decreasing and 50% (6/12) of the patients with increasing M65 serum concentrations after surgery (p = 0.028). In conclusion, M65 as marker is likely to be valuable to identify patients with a high incidence of systemic disease.
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