ArticleJournal of neuro-oncology2010
Predictive value of multimodality MRI using conventional, perfusion, and spectroscopy MR in anaplastic transformation of low-grade oligodendrogliomas.
Article in Journal of neuro-oncology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- Optimal differentiation of high- and low-grade glioma and metastasis: a meta-analysis of perfusion, diffusion, and spectroscopy metrics.Neuroradiology · 2016Pooled it
- The role of imaging in the management of adults with diffuse low grade glioma: A systematic review and evidence-based clinical practice guideline.Journal of neuro-oncology · 2015Guideline
- Evaluation of the diagnostic performance of magnetic resonance spectroscopy in brain tumors: a systematic review and meta-analysis.PloS one · 2014Pooled it
- Surveillance imaging frequency in adult patients with lower-grade (WHO Grade 2 and 3) gliomas.Neuro-oncology · 2022Review
- Identifying biomarkers associated with tumor growth rate: a longitudinal preoperative magnetic resonance imaging follow-up of low-grade gliomas.Annals of translational medicine · 2022Article
- Longitudinal structural and perfusion MRI enhanced by machine learning outperforms standalone modalities and radiological expertise in high-grade glioma surveillance.Neuroradiology · 2021Article
- GliMR: Cross-Border Collaborations to Promote Advanced MRI Biomarkers for Glioma.Journal of medical and biological engineering · 2021Review
- Imaging growth as a predictor of grade of malignancy and aggressiveness of IDH-mutant and 1p/19q-codeleted oligodendrogliomas in adults.Neuro-oncology · 2020Article
- Correction to: Advanced imaging in adult diffusely infiltrating low-grade gliomas.Insights into imaging · 2020Article
- Advanced imaging in adult diffusely infiltrating low-grade gliomas.Insights into imaging · 2019Review
- Imaging practice in low-grade gliomas among European specialized centers and proposal for a minimum core of imaging.Journal of neuro-oncology · 2018Article
- Tumor growth dynamics in serially-imaged low-grade glioma patients.Journal of neuro-oncology · 2018Article
- 'Low grade glioma': an update for radiologists.The British journal of radiology · 2017Review
- The Use of MR Perfusion Imaging in the Evaluation of Tumor Progression in Gliomas.Journal of Korean Neurosurgical Society · 2017Article
- Awake surgery for hemispheric low-grade gliomas: oncological, functional and methodological differences between pediatric and adult populations.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2016Review
- Heterogeneous Optimization Framework: Reproducible Preprocessing of Multi-Spectral Clinical MRI for Neuro-Oncology Imaging Research.Neuroinformatics · 2016Article
- Advanced MRI may complement histological diagnosis of lower grade gliomas and help in predicting survival.Journal of neuro-oncology · 2016Article
- Early Detection of Malignant Transformation in Resected WHO II Low-Grade Glioma Using Diffusion Tensor-Derived Quantitative Measures.PloS one · 2016Article
- Prediction of anaplastic transformation in low-grade oligodendrogliomas based on magnetic resonance spectroscopy and 1p/19q codeletion status.Journal of neuro-oncology · 2015Article
- Microfoci of malignant progression in diffuse low-grade gliomas: towards the creation of an intermediate grade in glioma classification?Virchows Archiv : an international journal of pathology · 2015Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of our study was to evaluate the role of proton magnetic resonance (MR) spectroscopy and MR perfusion in the follow-up of low-grade gliomas, since conventional MR imaging (MRI) is not reliable in detecting the passage from a low- to high-grade tumor. Twenty-one patients with a World Health Organisation (WHO) grade II glioma were followed up using proton MR spectroscopy, perfusion, and conventional MRIs. Follow-up MRIs had been performed at the third month of evolution and then twice a year, with an average of five MR studies per patient. Five out of the 21 patients had an anaplastic transformation. A choline to creatine ratio (choline/creatine ratio) above 2.4 is associated with an 83% risk of a malignant transformation in an average delay of 15.4 months. The choline/creatine ratio at this threshold was more efficient than perfusion MR in detecting the anaplastic transformation, with sensitivity of 80% and specificity of 94%. An increased choline/creatine ratio seemed to occur an average 15 months before the elevation of relative cerebral blood volume (rCBV). The mean annual growth of low-grade glioma was 3.65 mm. A growth rate higher than 3 mm per year was also correlated with greater risk of anaplastic transformation. Proton magnetic resonance spectroscopy should be recommended in the follow-up of low-grade gliomas since the choline/creatine ratio can predict anaplastic transformation before perfusion abnormalities, with high positive predictive value of 83%.
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