ArticlePloS one2009
Increasing incidence of pediatric type 1 diabetes mellitus in Southeastern Wisconsin: relationship with body weight at diagnosis.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Bariatric Surgery in Type 1 Diabetes Mellitus: A Systematic Review.Obesity surgery · 2016Pooled it
- Genetic pleiotropy underlying obesity and autoimmune disorders: a large-scale cross-trait gwas analysis in European ancestry populations.Journal of translational medicine · 2025Article
- Epidemiology of type 1 diabetes mellitus in children and adolescents: A 50-year, single-center experience.Journal of diabetes · 2024Article
- Pregnancy and diabetic ketoacidosis: fetal jeopardy and windows of opportunity.Frontiers in clinical diabetes and healthcare · 2023Article
- Article
- Increased Incidence of Type 1 Diabetes in Children and No Change in the Age of Diagnosis and BMI-SDS at the Onset - is the Accelerator Hypothesis not Working?Journal of clinical research in pediatric endocrinology · 2020Article
- Article
- Nucleotide-binding oligomerization domain-containing protein 2 (Nod2) modulates T1DM susceptibility by gut microbiota.Journal of autoimmunity · 2017Article
- Ethnic differences in association of high body mass index with early onset of Type 1 diabetes - Arab ethnicity as case study.PloS one · 2017Article
- The importance of the Non Obese Diabetic (NOD) mouse model in autoimmune diabetes.Journal of autoimmunity · 2016Review
- Incidence of type 1 diabetes mellitus during 26 years of observation and prevalence of diabetic ketoacidosis in the later years.European journal of pediatrics · 2015Observational
- Covariation of the incidence of type 1 diabetes with country characteristics available in public databases.PloS one · 2015Article
- Is the risk and nature of CVD the same in type 1 and type 2 diabetes?Current diabetes reports · 2013Review
- Rising incidence of type 1 diabetes in Belgrade children aged 0-14 years in the period from 1982 to 2005.Journal of endocrinological investigation · 2013Article
- Epidemiological pattern of newly diagnosed children with type 1 diabetes mellitus, Taif, Saudi Arabia.TheScientificWorldJournal · 2013Article
- Incidence of type 1 diabetes mellitus in Turkish children from the southeastern region of the country: a regional report.Journal of clinical research in pediatric endocrinology · 2013Article
- Polymorphisms in fatty acid binding protein 5 show association with type 2 diabetes.Diabetes research and clinical practice · 2011Article
- Diabetes trends among delivery hospitalizations in the U.S., 1994-2004.Diabetes care · 2010Article
- German new onset diabetes in the young incident cohort study: DiMelli study design and first-year results.The review of diabetic studies : RDS · 2010Article
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
introductionSeveral studies have confirmed the increasing rate of type 1 diabetes mellitus (T1DM) in children and the link with increasing BMI at diagnosis termed the 'accelerator hypothesis'. Our objective was to assess whether changing incidence of type 1 diabetes in a group of children and adolescent from the Midwest United States was associated with changes in BMI.
methodsData from 1618 (52.1% M/47.9% F) newly-diagnosed children and adolescents (<19 years) with T1DM, admitted to Children's Hospital of Wisconsin (CHW) between January 1995 and December 2004, was analyzed in relationship to body mass index (BMI) standard deviation score (SDS).
resultsAn overall, 10-year cumulative incidence of 27.92 per 100,000 (19.12 to 41.72/100,000) was observed, with an average yearly cumulative incidence of 2.39%. The increase was largest in the younger age groups, 0-4, 5-9, and 10-14 having an average yearly increase of 2.4, 2.3, and 3.0%, respectively, corresponding to a relative 10-year increase of 25.3, 33.8, and 38.0%, respectively. Age at diagnosis was inversely correlated with BMI SDS (p<0.001) and remained significant for both males and females.
conclusionsAnnual incidence of T1DM increased two-fold at CHW over the 10-year study period. The majority of the increase was observed in the youngest age groups, which also appeared to be the heaviest. This research adds to the growing literature supporting the hypothesis that excess weight gain during childhood may be a risk factor for early manifestation of T1DM.
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