ArticlePloS one2009
Impaired prefrontal hemodynamic maturation in autism and unaffected siblings.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Functional Near-Infrared Spectroscopy in the Study of Speech and Language Impairment Across the Life Span: A Systematic Review.American journal of speech-language pathology · 2020Pooled it
- Assessing Frontal Lobe Function on Verbal Fluency and Emotion Recall in Autism Spectrum Disorder by fNIRS.Journal of autism and developmental disorders · 2025Observational
- Mapping brain function in adults and young children during naturalistic viewing with high-density diffuse optical tomography.Human brain mapping · 2024Article
- Neurovascular crosstalk and cerebrovascular alterations: an underestimated therapeutic target in autism spectrum disorders.Frontiers in cellular neuroscience · 2023Review
- The use of functional near-infrared spectroscopy in tracking neurodevelopmental trajectories in infants and children with or without developmental disorders: a systematic review.Frontiers in psychiatry · 2023Review
- Near-infrared spectroscopy in child and adolescent neurodevelopmental disorders.PCN reports : psychiatry and clinical neurosciences · 2022Review
- Reduced Brain Activation in Response to Social Cognition Tasks in Autism Spectrum Disorder with and without Depression.Neuropsychiatric disease and treatment · 2021Article
- From Neurodevelopmental to Neurodegenerative Disorders: The Vascular Continuum.Frontiers in aging neuroscience · 2021Review
- Ventrolateral prefrontal hemodynamic responses in autism spectrum disorder with and without depression.PloS one · 2021Article
- Deficits in verbal fluency in presymptomaticJournal of neurology, neurosurgery, and psychiatry · 2020Article
- Use of Virtual Reality Working Memory Task and Functional Near-Infrared Spectroscopy to Assess Brain Hemodynamic Responses to Methylphenidate in ADHD Children.Frontiers in psychiatry · 2020Article
- Genetic influences on prefrontal activation during a verbal fluency task in children: A twin study using near-infrared spectroscopy.Brain and behavior · 2018Article
- fNIRS Studies on Hemispheric Asymmetry in Atypical Neural Function in Developmental Disorders.Frontiers in human neuroscience · 2017Review
- Rapid and Objective Assessment of Neural Function in Autism Spectrum Disorder Using Transient Visual Evoked Potentials.PloS one · 2016Article
- Optical Topography in Psychiatry: A Chip Off the Old Block or a New Look Beyond the Mind-Brain Frontiers?Frontiers in psychiatry · 2016Review
- Broader Autism Phenotype in Siblings of Children with ASD--A Review.International journal of molecular sciences · 2015Review
- Cognitive abilities in siblings of children with autism spectrum disorders.Experimental brain research · 2014Article
- Reduced interhemispheric functional connectivity of children with autism spectrum disorder: evidence from functional near infrared spectroscopy studies.Biomedical optics express · 2014Article
- Autistic traits below the clinical threshold: re-examining the broader autism phenotype in the 21st century.Neuropsychology review · 2011Review
- Scanning strategies do not modulate face identification: eye-tracking and near-infrared spectroscopy study.PloS one · 2010Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDysfunctions of the prefrontal cortex have been previously reported in individuals with autism spectrum disorders (ASD). Previous studies reported that first-degree relatives of individuals with ASD show atypical brain activity during tasks associated with social function. However, developmental changes in prefrontal dysfunction in ASD and genetic influences on the phenomena remain unclear. In the present study, we investigated the change in hemoglobin concentration in the prefrontal cortex as measured with near-infrared spectroscopy, in children and adults with ASD during the letter fluency test. Moreover, to clarify the genetic influences on developmental changes in the prefrontal dysfunction in ASD, unaffected siblings of the ASD participants were also assessed. METHODOLOGY/PRINCIPAL
findingsStudy participants included 27 individuals with high-functioning ASD, age- and IQ-matched 24 healthy non-affected siblings, and 27 unrelated healthy controls aged 5 to 39 years. The relative concentration of hemoglobin ([Hb]) in the prefrontal cortex was measured during the letter fluency task. For children, neither the [oxy-Hb] change during the task nor task performances differed significantly among three groups. For adults, the [oxy-Hb] increases during the task were significantly smaller in the bilateral prefrontal cortex in ASD than those in control subjects, although task performances were similar. In the adult siblings the [oxy-Hb] change was intermediate between those in controls and ASDs. CONCLUSION/SIGNIFICANCE: Although indirectly due to a cross-sectional design, the results of this study indicate altered age-related change of prefrontal activity during executive processing in ASD. This is a first near-infrared spectroscopy study that implies alteration in the age-related changes of prefrontal activity in ASD and genetic influences on the phenomena.
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Registered trials
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