ArticleHuman genetics1990
Loss of heterozygosity of the L-myc oncogene in human breast tumors.
Article in Human genetics, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 47 citations in OpenAlex.
- MYCL genotypes and loss of heterozygosity in non-small-cell lung cancer.British journal of cancer · 1996Article
- Genetic analysis of breast cancer progression.Journal of mammary gland biology and neoplasia · 1996Review
- MMTV-induced mutations in mouse mammary tumors: their potential relevance to human breast cancer.Breast cancer research and treatment · 1996Review
- Familial breast cancer and genes involved in breast carcinogenesis.Breast cancer research and treatment · 1995Review
- Tumor suppressor genes and their roles in breast cancer.Breast cancer research and treatment · 1994Review
- Chromosome 1 in human colorectal tumors. Cytogenetic research on structural changes and their significance.Human genetics · 1992Article
- Loss of heterozygosity on chromosome 17p13 in breast carcinomas identifies tumors with high proliferation index.The American journal of pathology · 1992Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies suggest that loss of heterozygosity may play an important role in various human neoplasia. Cytogenetic abnormalities detected in primary breast tumors led us to examine breast tumor DNAs for deletions. In the present study, we demonstrate, using restriction fragment length polymorphism (RFLP) analysis at the L-myc proto-oncogene (chromosome 1p32), a frequent loss of heterozygosity in primary breast tumor DNAs (55 out of 152 informative tumor DNAs). Most of these deletions appear to be limited to chromosome 1p. No correlation was observed between this genetic alteration and several parameters of each patient's history or characteristics of the tumor. However, a significantly (P = 0.011) shorter survival period after relapse was observed for patients with loss of heterozygosity at L-myc in primary tumor DNAs compared with patients with tumor DNAs lacking this alteration.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.