ArticleBiology of reproduction2010
Progesterone receptor-induced gene expression in primary mouse granulosa cell cultures.
Article in Biology of reproduction, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
20 citing papers in PubMed, 47 citations in OpenAlex.
- Secretory Profile Analysis of Human Granulosa Cell Line Following Gonadotropin Stimulation.International journal of molecular sciences · 2025Article
- Exposure to a phthalate mixture disrupts ovulatory progesterone receptor signaling in human granulosa cells in vitro†.Biology of reproduction · 2023Article
- Expression of PCOS candidate genes in bovine fetal and adult ovarian somatic cells.Reproduction & fertility · 2022Article
- Regulation of progesterone during follicular development by FSH and LH in sheep.Animal reproduction · 2022Article
- Article
- Progesterone Receptor Serves the Ovary as a Trigger of Ovulation and a Terminator of Inflammation.Cell reports · 2020Article
- Ovulation: Parallels With Inflammatory Processes.Endocrine reviews · 2019Review
- Ovarian Follicular Theca Cell Recruitment, Differentiation, and Impact on Fertility: 2017 Update.Endocrine reviews · 2018Review
- Anti-tumorigenic and Platinum-Sensitizing Effects of Apolipoprotein A1 and Apolipoprotein A1 Mimetic Peptides in Ovarian Cancer.Frontiers in pharmacology · 2018Article
- Gene expression profiling of upregulated mRNAs in granulosa cells of bovine ovulatory follicles following stimulation with hCG.Reproductive biology and endocrinology : RB&E · 2017Article
- Impact of Prunus Cerasus on PGR and HAS2 in Cumulus Cells and Fertility Outcome.Advanced pharmaceutical bulletin · 2016Article
- Progesterone-mediated effects on gene expression and oocyte-cumulus complex transport in the mouse fallopian tube.Reproductive biology and endocrinology : RB&E · 2015Article
- Global gene expression in granulosa cells of growing, plateau and atretic dominant follicles in cattle.Reproductive biology and endocrinology : RB&E · 2015Article
- Regulated expression of Rhox8 in the mouse ovary: evidence for the role of progesterone and RHOX5 in granulosa cells.Biology of reproduction · 2013Article
- DNA methylation and histone modifications are associated with repression of the inhibin α promoter in the rat corpus luteum.Endocrinology · 2012Article
- Nuclear receptor profiling of ovarian granulosa cell tumors.Hormones & cancer · 2011Article
- Steroid hormones content and proteomic analysis of canine follicular fluid during the preovulatory period.Reproductive biology and endocrinology : RB&E · 2010Article
- Luteinizing hormone receptor-stimulated progesterone production by preovulatory granulosa cells requires protein kinase A-dependent activation/dephosphorylation of the actin dynamizing protein cofilin.Molecular endocrinology (Baltimore, Md.) · 2010Article
- Scavenger receptor-B1 and luteal function in mice.Journal of lipid research · 2010Article
- Control of oocyte release by progesterone receptor-regulated gene expression.Nuclear receptor signaling · 2009Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The progesterone receptor (PGR) is induced by luteinizing hormone (LH) in granulosa cells of preovulatory follicles, and the PGR-A isoform is essential for ovulation based on the phenotypes of Pgr isoform-specific knockout mice. Although several genes regulated by PGR-A in vivo have been identified, whether these genes are primary targets of PGR-A or if their expression also depends on other signaling molecules that are induced by the LH surge has not been resolved. Therefore, to identify genes that are either induced or repressed by PGR in the absence of LH-mediated signaling cascades, we infected primary cultures of mouse granulosa cells with either PGR-A or PGR-B adenoviral vectors without or with R-5020 as a PGR ligand. Total RNA was extracted from infected cells at 16 h and analyzed by Affymetrix Mouse 430 2.0 microarrays. PGR-A in the presence or absence of ligand significantly induced approximately 50 genes 2-fold or more (local pooled error test at P <or= 0.01). Fewer and different genes were induced by PGR-B in the absence of ligand. Edn1, Apoa1, and Cited1 were primarily regulated by PGR-A as verified by additional RT-PCR analyses, suppression by the PGR antagonist RU486, and the lack of induction by protein kinase A, protein kinase C, or epidermal growth factor (EGF)-like factors pathways. PGR regulation of these genes was confirmed further by gene expression analyses in hormonally primed Pgr mutant mouse ovaries. Because Edn1, Apoa1, and Cited1 are known to regulate angiogenesis, PGR may affect the neovascularization of follicles that is initiated with ovulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.