ArticleJournal of neurophysiology2009
Context-dependent effects of NMDA receptors on precise timing information at the endbulb of Held in the cochlear nucleus.
Article in Journal of neurophysiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- Induction of Activity-Dependent Plasticity at Auditory Nerve Synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Time Course of Activity-Dependent Changes in Auditory Nerve Synapses Reveals Multiple Underlying Cellular Mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Minimal Number of Required Inputs for Temporally Precise Action Potential Generation in Auditory Brainstem Nuclei.Frontiers in cellular neuroscience · 2020Article
- Input timing for spatial processing is precisely tuned via constant synaptic delays and myelination patterns in the auditory brainstem.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Different pools of glutamate receptors mediate sensitivity to ambient glutamate in the cochlear nucleus.Journal of neurophysiology · 2015Article
- Skipped-stimulus approach reveals that short-term plasticity dominates synaptic strength during ongoing activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Activity-dependent, homeostatic regulation of neurotransmitter release from auditory nerve fibers.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- High-speed dynamic-clamp interface.Journal of neurophysiology · 2015Article
- Synaptic and circuit mechanisms promoting broadband transmission of olfactory stimulus dynamics.Nature neuroscience · 2015Article
- Inhibitory properties underlying non-monotonic input-output relationship in low-frequency spherical bushy neurons of the gerbil.Frontiers in neural circuits · 2015Article
- Target- and input-dependent organization of AMPA and NMDA receptors in synaptic connections of the cochlear nucleus.The Journal of comparative neurology · 2014Article
- Dynamic fidelity control to the central auditory system: synergistic glycine/GABAergic inhibition in the cochlear nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Stochastic properties of neurotransmitter release expand the dynamic range of synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Control of neuronal excitability by NMDA-type glutamate receptors in early developing binaural auditory neurons.The Journal of physiology · 2012Article
- Emergence of coordinated plasticity in the cochlear nucleus and cerebellum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Redefining the classification of AMPA-selective ionotropic glutamate receptors.The Journal of physiology · 2012Review
- Ultrastructure, synaptic organization, and molecular components of bushy cell networks in the anteroventral cochlear nucleus of the rhesus monkey.Neuroscience · 2011Article
- Auditory nerve fibers excite targets through synapses that vary in convergence, strength, and short-term plasticity.Journal of neurophysiology · 2010Article
- Development of glutamatergic synaptic transmission in binaural auditory neurons.Journal of neurophysiology · 2010Article
- Developmental mechanisms for suppressing the effects of delayed release at the endbulb of Held.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Many synapses contain both AMPA receptors (AMPAR) and N-methyl-d-aspartate receptors (NMDAR), but their different roles in synaptic computation are not clear. We address this issue at the auditory nerve fiber synapse (called the endbulb of Held), which is formed on bushy cells of the cochlear nucleus. The endbulb refines and relays precise temporal information to nuclei responsible for sound localization. The endbulb has a number of specializations that aid precise timing, including AMPAR-mediated excitatory postsynaptic currents (EPSCs) with fast kinetics. Voltage-clamp experiments in mouse brain slices revealed that slow NMDAR EPSCs are maintained at mature endbulbs, contributing a peak conductance of around 10% of the AMPAR-mediated EPSC. During repetitive synaptic activity, AMPAR EPSCs depressed and NMDAR EPSCs summated, thereby increasing the relative importance of NMDARs. This could impact temporal precision of bushy cells because of the slow kinetics of NMDARs. We tested this by blocking NMDARs and quantifying bushy cell spike timing in current clamp when single endbulbs were activated. These experiments showed that NMDARs contribute to an increased probability of firing, shorter latency, and reduced jitter. Dynamic-clamp experiments confirmed this effect and showed it was dose-dependent. Bushy cells can receive inputs from multiple endbulbs. When we applied multiple synaptic inputs in dynamic clamp, NMDARs had less impact on spike timing. NMDAR conductances much higher than mature levels could disrupt spiking, which may explain its downregulation during development. Thus mature NMDAR expression can support the conveying of precise temporal information at the endbulb, depending on the stimulus conditions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.