ReviewThe Journal of biological chemistry2009
Helicase-appended topoisomerases: new insight into the mechanism of directional strand transfer.
Review in The Journal of biological chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- Mechanism of Bloom syndrome complex assembly required for double Holliday junction dissolution and genome stability.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Selective toxicity of antibacterial agents-still a valid concept or do we miss chances and ignore risks?Infection · 2021Review
- The many lives of type IA topoisomerases.The Journal of biological chemistry · 2020Review
- Direct observation of DNA overwinding by reverse gyrase.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Quality control of homologous recombination.Cellular and molecular life sciences : CMLS · 2014Review
- Chromatin structure and dynamics in hot environments: architectural proteins and DNA topoisomerases of thermophilic archaea.International journal of molecular sciences · 2014Review
- Genome stability: recent insights in the topoisomerase reverse gyrase and thermophilic DNA alkyltransferase.Extremophiles : life under extreme conditions · 2014Review
- Reverse gyrase--recent advances and current mechanistic understanding of positive DNA supercoiling.Nucleic acids research · 2014Review
- The dissolution of double Holliday junctions.Cold Spring Harbor perspectives in biology · 2014Review
- Molecular mechanism of double Holliday junction dissolution.Cell & bioscience · 2014Review
- Top3α is required during the convergent migration step of double Holliday junction dissolution.PloS one · 2014Article
- Synthesis and dissolution of hemicatenanes by type IA DNA topoisomerases.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Synergic and opposing activities of thermophilic RecQ-like helicase and topoisomerase 3 proteins in Holliday junction processing and replication fork stabilization.The Journal of biological chemistry · 2012Article
- RMI1 promotes DNA replication fork progression and recovery from replication fork stress.Molecular and cellular biology · 2012Article
- Essential functions of C terminus of Drosophila Topoisomerase IIIα in double holliday junction dissolution.The Journal of biological chemistry · 2012Article
- Functional evaluation of four putative DNA-binding regions in Thermoanaerobacter tengcongensis reverse gyrase.Extremophiles : life under extreme conditions · 2011Article
- Separate and combined biochemical activities of the subunits of a naturally split reverse gyrase.The Journal of biological chemistry · 2010Article
- Rmi1 stimulates decatenation of double Holliday junctions during dissolution by Sgs1-Top3.Nature structural & molecular biology · 2010Article
- An essential DNA strand-exchange activity is conserved in the divergent N-termini of BLM orthologs.The EMBO journal · 2010Article
- Drosophila topo IIIalpha is required for the maintenance of mitochondrial genome and male germ-line stem cells.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA strand passage through an enzyme-mediated gate is a key step in the catalytic cycle of topoisomerases to produce topological transformations in DNA. In most of the reactions catalyzed by topoisomerases, strand passage is not directional; thus, the enzyme simply provides a transient DNA gate through which DNA transport is allowed and thereby resolves the topological entanglement. When studied in isolation, the type IA topoisomerase family appears to conform to this rule. Interestingly, type IA enzymes can carry out directional strand transport as well. We examined here the biochemical mechanism for directional strand passage of two type IA topoisomerases: reverse gyrase and a protein complex of topoisomerase III alpha and Bloom helicase. These enzymes are able to generate vectorial strand transport independent of the supercoiling energy stored in the DNA molecule. Reverse gyrase is able to anneal single strands, thereby increasing linkage number of a DNA molecule. However, topoisomerase III alpha and Bloom helicase can dissolve DNA conjoined with a double Holliday junction, thus reducing DNA linkage. We propose here that the helicase or helicase-like component plays a determinant role in the directionality of strand transport. There is thus a common biochemical ground for the directional strand passage for the type IA topoisomerases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.