Trial reportThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
The functional Val158Met polymorphism of COMT predicts interindividual differences in brain alpha oscillations in young men.
Trial report in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
43 citing papers in PubMed, 108 citations in OpenAlex.
- Trial
- COMT polymorphism modulates the resting-state EEG alpha oscillatory response to acute nicotine in male non-smokers.Genes, brain, and behavior · 2015Trial
- Inter- and intra-individual variability in alpha peak frequency.NeuroImage · 2014Trial
- Polymorphisms of ADORA2A modulate psychomotor vigilance and the effects of caffeine on neurobehavioural performance and sleep EEG after sleep deprivation.British journal of pharmacology · 2012Trial
- Trial
- The COMT rs4680 SNP participates in the regulation of the arousal threshold in patients with obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2026Observational
- Common Genomic and Proteomic Alterations Related to Disturbed Neural Oscillatory Activity in Schizophrenia.International journal of molecular sciences · 2025Review
- Genetic Foundations of Inter-individual Neurophysiological Variability.bioRxiv : the preprint server for biology · 2025Article
- Stable interindividual differences in modafinil's effect on vigilance during sleep deprivation.Frontiers in pharmacology · 2025Article
- Peak alpha frequency and electroencephalographic microstates are correlated with aggression in schizophrenia.Journal of psychiatric research · 2024Article
- Unraveling Catechol-O-Methyltransferase rs4680 SNP's Role in Patients' Response to Tramadol and Its Adverse Effects: A Pharmacogenetics Insight into Postoperative Pain Management.Journal of clinical medicine · 2023Article
- Genetic polymorphisms iniScience · 2022Article
- Calibrating rhythmic stimulation parameters to individual electroencephalography markers: The consistency of individual alpha frequency in practical lab settings.The European journal of neuroscience · 2022Article
- Brief segments of neurophysiological activity enable individual differentiation.Nature communications · 2021Observational
- Individual alpha peak frequency is slower in schizophrenia and related to deficits in visual perception and cognition.Scientific reports · 2021Article
- Rapid fast-delta decay following prolonged wakefulness marks a phase of wake-inertia in NREM sleep.Nature communications · 2020Article
- Article
- Abnormalities of Cortical Sources of Resting State Delta Electroencephalographic Rhythms Are Related to Epileptiform Activity in Patients With Amnesic Mild Cognitive Impairment Not Due to Alzheimer's Disease.Frontiers in neurology · 2020Article
- Inter- and Intra-individual Variability in Brain Oscillations During Sports Motor Imagery.Frontiers in human neuroscience · 2020Article
- Effects of RF-EMF on the Human Resting-State EEG-the Inconsistencies in the Consistency. Part 1: Non-Exposure-Related Limitations of Comparability Between Studies.Bioelectromagnetics · 2019Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Individual patterns of the electroencephalogram (EEG) in wakefulness and sleep are among the most heritable traits in humans, yet distinct genetic and neurochemical mechanisms underlying EEG phenotypes are largely unknown. A functional polymorphism in the gene encoding catechol-O-methyltransferase (COMT), an enzyme playing an important role in cortical dopamine metabolism, causes a common substitution of methionine (Met) for valine (Val) at codon 158 of COMT protein. Val allele homozygotes exhibit higher COMT activity and lower dopaminergic signaling in prefrontal cortex than Met/Met homozygotes. Evidence suggests that this polymorphism affects executive functions in healthy individuals. We hypothesized that it also modulates functional aspects of EEG in wakefulness and sleep. EEG recordings were conducted twice on separate occasions in 10 Val/Val and 12 Met/Met allele carriers (all men) in wakefulness, and in baseline and recovery sleep before and after 40 h prolonged waking. During sleep deprivation, subjects received placebo and modafinil in randomized, cross-over manner. We show that the Val158Met polymorphism predicts stable and frequency-specific, interindividual variation in brain alpha oscillations. Alpha peak frequency in wakefulness was 1.4 Hz slower in Val/Val genotype than in Met/Met genotype. Moreover, Val/Val allele carriers exhibited less 11-13 Hz activity than Met/Met homozygotes in wakefulness, rapid-eye-movement (REM) sleep, and non-REM sleep. This difference was resistant against the effects of sleep deprivation and modafinil. The data demonstrate that mechanisms involving COMT contribute to interindividual differences in brain alpha oscillations, which are functionally related to executive performance such as counting tendency on a random number generation task in young adults.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.