ArticleJournal of virology2009
Receptor binding and low pH coactivate oncogenic retrovirus envelope-mediated fusion.
Article in Journal of virology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 28 citations in OpenAlex.
- Genomic Sequencing and Analysis of New Variants of Enzootic Nasal Tumour Virus Type 2 Revealed Recombination Events between Different Sublineages.Veterinary medicine and science · 2026Article
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- Enzootic nasal tumor virus type 2 envelope of goats acts as a retroviral oncogene in cell transformation.Virus genes · 2021Article
- A Virion-Based Assay for Glycoprotein Thermostability Reveals Key Determinants of Filovirus Entry and Its Inhibition.Journal of virology · 2020Article
- Reconstruction of the cell entry pathway of an extinct virus.PLoS pathogens · 2018Article
- Residues 28 to 39 of the Extracellular Loop 1 of Chicken NaJournal of virology · 2018Article
- Fusion of Enveloped Viruses in Endosomes.Traffic (Copenhagen, Denmark) · 2016Review
- Cross-resistance mechanism of respiratory syncytial virus against structurally diverse entry inhibitors.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Reversible and efficient activation of HIV-1 cell entry by a tyrosine-sulfated peptide dissects endocytic entry and inhibitor mechanisms.Journal of virology · 2014Article
- IFITMs restrict the replication of multiple pathogenic viruses.Journal of molecular biology · 2013Review
- Captured retroviral envelope syncytin gene associated with the unique placental structure of higher ruminants.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Betaretroviral envelope subunits are noncovalently associated and restricted to the mammalian class.Journal of virology · 2013Article
- IFITM proteins restrict viral membrane hemifusion.PLoS pathogens · 2013Article
- Critical role of leucine-valine change in distinct low pH requirements for membrane fusion between two related retrovirus envelopes.The Journal of biological chemistry · 2012Article
- Filovirus entry: a novelty in the viral fusion world.Viruses · 2012Review
- Jaagsiekte sheep retrovirus pseudotyped lentiviral vector-mediated gene transfer to fetal ovine lung.Gene therapy · 2012Article
- Membrane fusion and cell entry of XMRV are pH-independent and modulated by the envelope glycoprotein's cytoplasmic tail.PloS one · 2012Article
- A receptor-based switch that regulates anthrax toxin pore formation.PLoS pathogens · 2011Article
- Receptor binding enables botulinum neurotoxin B to sense low pH for translocation channel assembly.Cell host & microbe · 2011Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Fusion of enveloped viruses with host cells is triggered by either receptor binding or low pH but rarely requires both except for avian sarcoma leukosis virus (ASLV). We recently reported that membrane fusion mediated by an oncogenic Jaagsiekte sheep retrovirus (JSRV) envelope (Env) requires an acidic pH, yet receptor overexpression is required for this process to occur. Here we show that a soluble form of the JSRV receptor, sHyal2, promoted JSRV Env-mediated fusion at a low pH in normally fusion-negative cells and that this effect was blocked by a synthetic peptide analogous to the C-terminal heptad repeat of JSRV Env. In contrast to the receptor of ASLV, sHyal2 induced pronounced shedding of the JSRV surface subunit, as well as unstable conformational rearrangement of its transmembrane (TM) subunit, yet full activation of JSRV Env fusogenicity, associated with strong TM oligomerization, required both sHyal2 and low pH. Consistently, sHyal2 enabled transduction of nonpermissive cells by JSRV Env pseudovirions, with low efficiency, but substantially blocked viral entry into permissive cells at both binding and postbinding steps, indicating that sHyal2 prematurely activates JSRV Env-mediated fusion. Altogether, our study supports a model that receptor priming promotes fusion activation of JSRV Env at a low pH, and that the underlying mechanism is likely to be different from that of ASLV. Thus, JSRV may provide a useful alternate model for the better understanding of virus fusion and cell entry.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.