ArticleProceedings. Biological sciences2009
Phospholamban S-nitrosylation modulates Starling response in fish heart.
Article in Proceedings. Biological sciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 60 citations in OpenAlex.
- Reduced Cx43 S-nitrosylation protects against cardiac stress-induced arrhythmias and myocardial injury in Duchenne muscular dystrophy.Cardiovascular research · 2026Article
- The cardiac response of the goldfish Carassius auratus to environmental hypoxia: from hemodynamics to mitochondria.Fish physiology and biochemistry · 2025Article
- Cardiac Hypoxia Tolerance in Fish: From Functional Responses to Cell Signals.International journal of molecular sciences · 2023Review
- The goldfish Carassius auratus: an emerging animal model for comparative cardiac research.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2022Review
- Hypoxic and Thermal Stress: Many Ways Leading to the NOS/NO System in the Fish Heart.Antioxidants (Basel, Switzerland) · 2021Review
- The Hypoxia Tolerance of the Goldfish (Antioxidants (Basel, Switzerland) · 2020Article
- MS-based proteomic analysis of cardiac response to hypoxia in the goldfish (Carassius auratus).Scientific reports · 2019Article
- Hypoxia Tolerance in Teleosts: Implications of Cardiac Nitrosative Signals.Frontiers in physiology · 2018Review
- Disulfide-activated protein kinase G Iα regulates cardiac diastolic relaxation and fine-tunes the Frank-Starling response.Nature communications · 2016Article
- S-Nitrosylation of Calcium-Handling Proteins in Cardiac Adrenergic Signaling and Hypertrophy.Circulation research · 2015Article
- Nitrite as Direct S-Nitrosylating Agent of Kir2.1 Channels.International scholarly research notices · 2014Article
- Strategies for hypoxia adaptation in fish species: a review.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2013Review
- Regulation of cardiovascular cellular processes by S-nitrosylation.Biochimica et biophysica acta · 2012Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Frank-Starling mechanism is a fundamental property of the vertebrate heart, which allows the myocardium to respond to increased filling pressure with a more vigorous contraction of its lengthened fibres. In mammals, myocardial stretch increases cardiac nitric oxide (NO) release from both vascular endothelium and cardiomyocytes. This facilitates myocardial relaxation and ventricular diastolic distensibility, thus influencing the Frank-Starling mechanism. In the in vitro working heart of the eel Anguilla anguilla, we previously showed that an endogenous NO release affects the Frank-Starling response making the heart more sensitive to preload. Using the same bioassay, we now demonstrate that this effect is confirmed in the presence of the exogenous NO donor S-nitroso-N-acetyl penicillamine, is independent from endocardial endothelium and guanylate cyclase/cGMP/protein kinase G and cAMP/protein kinase A pathways, involves a PI(3)kinase-mediated activation of endothelial NO synthase and a modulation of the SR-CA(2+)ATPase (SERCA2a) pumps. Furthermore, we show that NO influences cardiac response to preload through S-nitrosylation of phospholamban and consequent activation of SERCA2a. This suggests that in the fish heart NO modulates the Frank-Starling response through a beat-to-beat regulation of calcium reuptake and thus of myocardial relaxation. We propose that this mechanism represents an important evolutionary step for the stretch-induced intrinsic regulation of the vertebrate heart, providing, at the same time, a stimulus for mammalian-oriented studies.
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