ArticleEuropean journal of cell biology2009
Golgi polarity does not correlate with speed or persistence of freely migrating fibroblasts.
Article in European journal of cell biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
14 citing papers in PubMed.
- Persistent cell migration emerges from a coupling between protrusion dynamics and polarized trafficking.eLife · 2022Article
- The Golgi microtubules regulate single cell durotaxis.EMBO reports · 2021Article
- Golgi-associated microtubules are fast cargo tracks and required for persistent cell migration.EMBO reports · 2020Article
- Golgi Stabilization, Not Its Front-Rear Bias, Is Associated with EMT-Enhanced Fibrillar Migration.Biophysical journal · 2018Article
- Enucleated cells reveal differential roles of the nucleus in cell migration, polarity, and mechanotransduction.The Journal of cell biology · 2018Article
- Nonrandom γ-TuNA-dependent spatial pattern of microtubule nucleation at the Golgi.Molecular biology of the cell · 2017Article
- RCAN1.4 regulates VEGFR-2 internalisation, cell polarity and migration in human microvascular endothelial cells.Angiogenesis · 2017Article
- The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase.EMBO reports · 2016Article
- Microfluidic platform to evaluate migration of cells from patients with DYT1 dystonia.Journal of neuroscience methods · 2014Article
- Gα12 structural determinants of Hsp90 interaction are necessary for serum response element-mediated transcriptional activation.Molecular pharmacology · 2014Article
- Mitochondrial localization and the persistent migration of epithelial cancer cells.Biophysical journal · 2013Article
- Intravital imaging of a spheroid-based orthotopic model of melanoma in the mouse ear skin.Intravital · 2013Article
- Migrating fibroblasts reorient directionality by a metastable, PI3K-dependent mechanism.The Journal of cell biology · 2012Article
- Short-term molecular polarization of cells on symmetric and asymmetric micropatterns.Soft matter · 2010Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The polarization of the Golgi has long been thought to be important for cell migration. Here we show that Rat2 cells at the edge of an artificial wound repolarize the Golgi relative to the nucleus to face the direction of migration into the wound. However, in the absence of cues from neighboring cells, individual cells do not display Golgi polarity relative to the direction in which they are moving. Instead, the positioning of the Golgi relative to the nucleus remains relatively constant over time and does not reflect changes in the direction of migration. Consistent with this observation, we observe only a slight bias in Golgi positioning to the front of the nucleus, and this bias is not higher during periods of time when the cell is moving in a persistent manner. Taken together, these data suggest that Golgi polarity is not a requirement for cell migration.
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Registered trials
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