ArticleBMC neuroscience2009
Regulation of cerebrospinal fluid production by caffeine consumption.
Article in BMC neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 70 citations in OpenAlex.
- Impact of caffeine consumption on headache severity, sleep quality, and psychiatric symptoms in patients with idiopathic intracranial hypertension: a cross-sectional study.The journal of headache and pain · 2025Article
- Aberrant adenosine ANature communications · 2025Article
- CSF and venous blood flow from childhood to adulthood studied by real-time phase-contrast MRI.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Article
- A hidden pathophysiology of endolymphatic hydrops: case report of a patient with spontaneous intracranial hypotension presenting with sudden sensorineural hearing loss with vertigo.Frontiers in neurology · 2024Article
- Approaches for Increasing Cerebral Efflux of Amyloid-β in Experimental Systems.Journal of Alzheimer's disease : JAD · 2024Review
- Therapeutic Potential of Heterocyclic Compounds Targeting Mitochondrial Calcium Homeostasis and Signaling in Alzheimer's Disease and Parkinson's Disease.Antioxidants (Basel, Switzerland) · 2023Review
- Are standing osmotic gradients the main driver of cerebrospinal fluid production? A computational analysis.Fluids and barriers of the CNS · 2023Article
- Principal components from untargeted cerebrospinal fluid metabolomics associated with Alzheimer's disease biomarkers.Neurobiology of aging · 2022Article
- Treating Spontaneous Intracranial Hypotension with an Anesthetic Modality: The Role of the Epidural Blood Patch.Life (Basel, Switzerland) · 2022Article
- Tea consumption and risk of incident dementia: A prospective cohort study of 377 592 UK Biobank participants.Translational psychiatry · 2022Article
- Article
- [Post-dural puncture headache].Der Nervenarzt · 2021Article
- [Post-dural puncture headache].Schmerz (Berlin, Germany) · 2021Review
- Neuroprotective Effects of Coffee Bioactive Compounds: A Review.International journal of molecular sciences · 2020Review
- [Dependency of intraocular pressure on body posture in glaucoma patients : New approaches to pathogenesis and treatment].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2020Review
- Review
- The role of intracranial pressure in glaucoma and therapeutic implications.Eye (London, England) · 2020Review
- Spontaneous Intracranial Hypotension Associated with Postural Tachycardia Syndrome.Internal medicine (Tokyo, Japan) · 2019Article
- Impact of Coffee and Cacao Purine Metabolites on Neuroplasticity and Neurodegenerative Disease.Neurochemical research · 2019Review
- AMolecular neurobiology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCaffeine is the most commonly consumed psycho-stimulant in the world. The effects of caffeine on the body have been extensively studied; however, its effect on the structure of the brain has not been investigated to date.
resultsIn the present study we found that the long-term consumption of caffeine can induce ventriculomegaly; this was observed in 40% of the study rats. In the caffeine-treated rats with ventriculomegaly, there was increased production of CSF, associated with the increased expression of Na(+), K(+)-ATPase and increased cerebral blood flow (CBF). In contrast to the chronic effects, acute treatment with caffeine decreased the production of CSF, suggesting 'effect inversion' associated with caffeine, which was mediated by increased expression of the A1 adenosine receptor, in the choroid plexus of rats chronically treated with caffeine. The involvement of the A1 adenosine receptor in the effect inversion of caffeine was further supported by the induction of ventriculomegaly and Na+, K+-ATPase, in A1 agonist-treated rats.
conclusionThe results of this study show that long-term consumption of caffeine can induce ventriculomegaly, which is mediated in part by increased production of CSF. Moreover, we also showed that adenosine receptor signaling can regulate the production of CSF by controlling the expression of Na(+), K(+)-ATPase and CBF.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.