Trial reportPediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology2010
Relationship between infant weight gain and later asthma.
Trial report in Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Effect of the INSIGHT Responsive Parenting Intervention on Rapid Infant Weight Gain and Overweight Status at Age 1 Year: A Randomized Clinical Trial.JAMA pediatrics · 2016Trial
- The Intervention Nurses Start Infants Growing on Healthy Trajectories (INSIGHT) study.BMC pediatrics · 2014Trial
- Associations of postnatal growth with asthma and atopy: the PROBIT Study.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2013Trial
- Genetic research on childhood obesity and asthma: exploring genetic risk factors and biological mechanisms.Pediatric research · 2026Review
- Relationship between BMI-SDS trajectories and childhood asthma: a prospective cohort study from the Japan Environment and Children's Study.Environmental health and preventive medicine · 2026Article
- Early-life weight gain is associated with non-atopic asthma in childhood.The World Allergy Organization journal · 2022Article
- Association of Growth Trajectory Profiles with Asthma Development in Infants Hospitalized with Bronchiolitis.The journal of allergy and clinical immunology. In practice · 2022Article
- Respiratory morbidity, atopy and asthma at school age in preterm infants aged 32-35 weeks.European journal of pediatrics · 2019Observational
- Asthma, Rhinoconjunctivitis, Eczema, and the Association with Perinatal Anthropometric Factors in Vietnamese Children.Scientific reports · 2019Article
- Early Life Weight Gain and Development of Childhood Asthma in a Prospective Birth Cohort.Annals of the American Thoracic Society · 2018Article
- Overweight/obesity status in preschool children associates with worse asthma but robust improvement on inhaled corticosteroids.The Journal of allergy and clinical immunology · 2018Article
- Milk: a postnatal imprinting system stabilizing FoxP3 expression and regulatory T cell differentiation.Clinical and translational allergy · 2016Review
- Milk--A Nutrient System of Mammalian Evolution Promoting mTORC1-Dependent Translation.International journal of molecular sciences · 2015Review
- Influence of childhood growth on asthma and lung function in adolescence.The Journal of allergy and clinical immunology · 2015Article
- Postnatal growth and the heterogeneity of preschool wheeze.The Journal of pediatrics · 2015Article
- Peak weight and height velocity to age 36 months and asthma development: the Norwegian Mother and Child Cohort Study.PloS one · 2015Article
- The potential mechanistic link between allergy and obesity development and infant formula feeding.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2014Review
- Fetal growth and risk of childhood asthma and allergic disease.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2012Review
- Perinatal programming of childhood asthma: early fetal size, growth trajectory during infancy, and childhood asthma outcomes.Clinical & developmental immunology · 2012Review
- Patterns of fetal and infant growth are related to atopy and wheezing disorders at age 3 years.Thorax · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
Like obesity, the prevalence of asthma has increased over the past several decades. Accelerated patterns of infant growth have been associated with obesity and its co-morbidities. We aimed to determine if infant weight gain pattern is associated with asthma development later in childhood. Birth weight, growth, pulmonary function, and symptom data were collected in a trial of 2- to 3-yr-old children at-risk for asthma randomized to a 2-yr treatment with inhaled corticosteroids or placebo followed by a 1-yr observation period of study medication. Patterns of infant weight gain between birth and study enrollment were categorized as accelerated, average, or decelerated. Regression analyses were used to test the effects of infant weight gain pattern prior to study enrollment on outcomes during the observation year and at study conclusion while adjusting for demographics, baseline symptom severity, study treatment, and atopic indicators. Among the 197 study participants, early life weight gain pattern was not associated with daily asthma symptoms or lung function at the study's conclusion. However, both prednisone courses (p = 0.01) and urgent physician visits (p < 0.001) were significantly associated with weight gain pattern with fewer exacerbations occurring amongst those with a decelerated weight gain pattern. We conclude that early life patterns of weight change were associated with subsequent asthma exacerbations, but were not associated with asthma symptoms or pulmonary function during the pre-school years for these children at-risk for asthma.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.