ArticleBrain pathology (Zurich, Switzerland)2010
A topographic study of minicolumnar core width by lamina comparison between autistic subjects and controls: possible minicolumnar disruption due to an anatomical element in-common to multiple laminae.
Article in Brain pathology (Zurich, Switzerland), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed, 87 citations in OpenAlex.
- Contracted functional connectivity profiles in autism.Molecular autism · 2024Article
- Neuronal and glial cell number is altered in a cortical layer-specific manner in autism.Autism : the international journal of research and practice · 2021Article
- Transcranial Magnetic Stimulation in Autism Spectrum Disorders: Neuropathological Underpinnings and Clinical Correlations.Seminars in pediatric neurology · 2020Review
- Targeting Gamma-Related Pathophysiology in Autism Spectrum Disorder Using Transcranial Electrical Stimulation: Opportunities and Challenges.Autism research : official journal of the International Society for Autism Research · 2020Article
- Non-invasive Brain Stimulation for the Rehabilitation of Children and Adolescents With Neurodevelopmental Disorders: A Systematic Review.Frontiers in psychology · 2019Article
- The Protracted Maturation of Associative Layer IIIC Pyramidal Neurons in the Human Prefrontal Cortex During Childhood: A Major Role in Cognitive Development and Selective Alteration in Autism.Frontiers in psychiatry · 2019Article
- Non-Invasive Brain Stimulation for Children with Autism Spectrum Disorders: A Short-Term Outcome Study.Behavioral sciences (Basel, Switzerland) · 2017Article
- The Number of Parvalbumin-Expressing Interneurons Is Decreased in the Prefrontal Cortex in Autism.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Ultrasound and Autism Spectrum Disorder.Australasian journal of ultrasound in medicine · 2016Article
- Abnormal Changes of Brain Cortical Anatomy and the Association with Plasma MicroRNA107 Level in Amnestic Mild Cognitive Impairment.Frontiers in aging neuroscience · 2016Article
- Neuromodulation integrating rTMS and neurofeedback for the treatment of autism spectrum disorder: an exploratory study.Applied psychophysiology and biofeedback · 2014Article
- Disturbed cingulate glutamate metabolism in adults with high-functioning autism spectrum disorder: evidence in support of the excitatory/inhibitory imbalance hypothesis.Molecular psychiatry · 2014Article
- Prefrontal cortical minicolumn: from executive control to disrupted cognitive processing.Brain : a journal of neurology · 2014Review
- Autism as a sequence: from heterochronic germinal cell divisions to abnormalities of cell migration and cortical dysplasias.Medical hypotheses · 2014Article
- A computational model for the loss of neuronal organization in microcolumns.Biophysical journal · 2014Article
- The utility of patient specific induced pluripotent stem cells for the modelling of Autistic Spectrum Disorders.Psychopharmacology · 2014Review
- Convergent synaptic and circuit substrates underlying autism genetic risks.Frontiers in biology · 2014Article
- A New Methodology of Viewing Extra-Axial Fluid and Cortical Abnormalities in Children with Autism via Transcranial Ultrasonography.Frontiers in human neuroscience · 2014Article
- Convergence of circuit dysfunction in ASD: a common bridge between diverse genetic and environmental risk factors and common clinical electrophysiology.Frontiers in cellular neuroscience · 2014Review
- An evo-devo approach to thyroid hormones in cerebral and cerebellar cortical development: etiological implications for autism.Frontiers in endocrinology · 2014Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Radial cell minicolumns are basic cytoarchitectonic motifs of the mammalian neocortex. Recent studies reveal that autism is associated with a "minicolumnopathy" defined by decreased columnar width and both a diminished and disrupted peripheral neuropil compartment. This study further characterizes this cortical deficit by comparing minicolumnar widths across layers. Brains from seven autistic patients and an equal number of age-matched controls were celloidin embedded, serially sectioned at 200 microm and Nissl stained with gallocyanin. Photomicrograph mosaics of the cortex were analyzed with computerized imaging methods to determine minicolumnar width at nine separate neocortical areas: Brodmann Area's (BA) 3b, 4, 9, 10, 11, 17, 24, 43 and 44. Each area was assessed at supragranular, granular and infragranular levels. Autistic subjects had smaller minicolumns whose dimensions varied according to neocortical area. The greatest difference between autistic and control groups was observed in area 44. The interaction of diagnosis x cortical area x lamina (F(16,316) = 1.33; P = 0.175) was not significant. Diminished minicolumnar width across deep and superficial neocortical layers most probably reflects involvement of shared constituents among the different layers. In this article we discuss the possible role of double bouquet and pyramidal cells in the translaminar minicolumnar width narrowing observed in autistic subjects.
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